BRCA1 antibody

Catalog No. ABIN965696

Product Details anti-BRCA1 Antibody

Target: BRCA1 (Breast Cancer 1 (BRCA1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BRCA1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Specificity: BRCA1 (Ab-1423) antibody detects endogenous levels of total BRCA1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human BRCA1 around the phosphorylation site of serine 1423 (H-G-SP-Q-P).

Application Details

Application Notes: IHC: 1:50-1:100.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100ug/100ul.

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-BRCA1 antibody (ABIN965696)

Greenberg, Sobhian, Pathania, Cantor, Nakatani, Livingston: "Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes." in: Genes & development, Vol. 20, Issue 1, pp. 34-46, (2006) (PubMed).

Arlt, Xu, Durkin, Casper, Kastan, Glover: "BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function." in: Molecular and cellular biology, Vol. 24, Issue 15, pp. 6701-9, (2004) (PubMed).

Zhang, Willers, Feng, Ghosh, Kim, Weaver, Chung, Powell, Xia: "Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair." in: Molecular and cellular biology, Vol. 24, Issue 2, pp. 708-18, (2003) (PubMed).

Kim, Xu, Kastan: "Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage." in: Genes & development, Vol. 16, Issue 5, pp. 560-70, (2002) (PubMed).

Tibbetts, Cortez, Brumbaugh, Scully, Livingston, Elledge, Abraham: "Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress." in: Genes & development, Vol. 14, Issue 23, pp. 2989-3002, (2000) (PubMed).

Target Details for BRCA1

Target: BRCA1 (Breast Cancer 1 (BRCA1))

Alternative Name: BRCA1 (BRCA1 Products)

Synonyms: BRCAI antibody, BRCC1 antibody, BROVCA1 antibody, IRIS antibody, PNCA4 antibody, PPP1R53 antibody, PSCP antibody, RNF53 antibody, iris antibody, pscp antibody, brcai antibody, brcc1 antibody, rnf53 antibody, brca1 antibody, BRCA1 antibody, LOC100224649 antibody, BRCA1, DNA repair associated antibody, breast cancer 1 antibody, breast cancer 1, early onset antibody, breast cancer 1 L homeolog antibody, BRCA1 antibody, brca1 antibody, LOC755086 antibody, Brca1 antibody, brca1.L antibody

Pathways: Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus