c-FOS antibody (Middle Region)

Catalog No. ABIN965712

Product Details anti-c-FOS Antibody

Target: c-FOS (c-Fos) (c-Fos)

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This c-FOS antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Mouse (Murine), Rat (Rattus)

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Proto-oncogene c-Fos (FOS) detection. Tested with WB in Human, Mouse, Rat.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human C-FOS, identical to the related rat and mouse sequences.< br/>Immunogen was affinity purified.

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Sodium azide, Thimerosal (Merthiolate)

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.

References for anti-c-FOS antibody (ABIN965712)

Grigoriadis, Wang, Wagner: "Fos and bone cell development: lessons from a nuclear oncogene." in: Trends in genetics : TIG, Vol. 11, Issue 11, pp. 436-41, (1996) (PubMed).

Saez, Rutberg, Mueller, Oppenheim, Smoluk, Yuspa, Spiegelman: "c-fos is required for malignant progression of skin tumors." in: Cell, Vol. 82, Issue 5, pp. 721-32, (1995) (PubMed).

Barker, Rabin, Watson, Breg, Ruddle, Verma: "Human c-fos oncogene mapped within chromosomal region 14q21----q31." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 81, Issue 18, pp. 5826-30, (1984) (PubMed).

Target Details for c-FOS

Target: c-FOS (c-Fos) (c-Fos)

Alternative Name: Proto-oncogene c-Fos (c-Fos Products)

Synonyms: AP-1 antibody, C-FOS antibody, p55 antibody, c-fos antibody, D12Rfj1 antibody, cFos antibody, cFOS antibody, fos antibody, Fos proto-oncogene, AP-1 transcription factor subunit antibody, FBJ osteosarcoma oncogene antibody, proto-oncogene c-Fos-like antibody, FOS antibody, Fos antibody, LOC101078177 antibody

Background: The human oncogene c-fos is cellular homolog of the transforming gene of Finkel-Biskis-Jinkins (FBJ) murine osteosarcoma virus which was mapped to a single human chromosome. c-Fos is encoded by the FOS gene. FOS was the first transcription factor identified that has a critical function in regulating the development of cells destined to form and maintain the skeleton. FOS is also a major component of the activator protein-1 (AP-1) transcription factor complex, which includes members of the JUN family. c-fos is a major nuclear target for signal transduction pathways involved in the regulation of cell growth, differentiation, and transformation. Using transgenic and knockout mice, Grigoriadis et al. (1995) established a unique role for the proto-oncogene and nuclear transcription factor, Fos, in regulating the differentiation and activity of specific bone cell populations, both during normal development and in bone disease.

Pathways: S100 Proteins