KIT antibody

Catalog No. ABIN965728

This Monoclonal antibody specifically detects KIT in ELISA. It exhibits reactivity toward Human and has been mentioned in 3+ publications.

Quick Overview for KIT antibody (ABIN965728)

Target: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Reactivity: Human

Host: Please inquire

Clonality: Monoclonal

Conjugate: This KIT antibody is un-conjugated

Application: ELISA

Product Details anti-KIT Antibody

Specificity: Ni-NTA purified truncated recombinant C-kit expressed in E. Coli strain BL21 (DE3)

Purification: Antibodies are purified by protein A affinity chromatography

Isotype: IgG1

Application Details

Application Notes: Dilution ELISA: Propose dilution 1: 10,000
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: -20 °C

References for anti-KIT antibody (ABIN965728)

Mojica, Saxena, Starostik, Cheney: "CD117+ small cell lung cancer lacks the asp 816-->val point mutation in exon 17." in: Histopathology, Vol. 47, Issue 5, pp. 517-22, (2005) (PubMed).

Tong, Liu, Zhang, Xiong, Liu, Zhang: "Expression of c-kit messenger ribonucleic acid and c-kit protein in sigmoid colon of patients with slow transit constipation." in: International journal of colorectal disease, Vol. 20, Issue 4, pp. 363-7, (2005) (PubMed).

Nakai, Nonomura, Oka, Shiba, Arai, Nakayama, Inoue, Nishimura, Aozasa, Mizutani, Miki, Okuyama: "KIT (c-kit oncogene product) pathway is constitutively activated in human testicular germ cell tumors." in: Biochemical and biophysical research communications, Vol. 337, Issue 1, pp. 289-96, (2005) (PubMed).

Target Details for KIT

Target: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Alternative Name: C-Kit

Background: C-kit (CD117,145kDa) functions as a tyrosine kinase receptor which becomes activated upon binding of its ligand SCF (stem-cell factor), the C-kit gene encodes the human homolog of the proto-oncogene ckit. which was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT is a type 3 transmembrane receptor for MGF (mast cell growth factor). Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism.

Gene ID: 3815

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity