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CHEK1 antibody (C-Term)

CHEK1 Reactivity: Human IHC Host: Rabbit Polyclonal unconjugated

Catalog No. ABIN965880

Datasheet as PDF

Target See all CHEK1 Antibodies

CHEK1 (Checkpoint Kinase 1 (CHEK1))
Binding Specificity
36

27

19

15

9

7

6

6

5

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
C-Term
Reactivity
170

111

61

16

11

8

6

6

6

4

4

3

2

1

1
Human
Host
183

12

5

5
Rabbit
Compatible Secondaries
Clonality
184

22
Polyclonal
Conjugate
112

11

9

8

4

4

4

4

4

4

4

4

4

3

3

3

3

3

3

3

3

3

3
This CHEK1 antibody is un-conjugated
Application
155

80

48

41

40

33

28

15

10

10

7

6

3

3

2

1

1
Immunohistochemistry (IHC)

Purification

Purified by antigen-specific affinity chromatography.

Immunogen

Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human CHEK1(Serine/threonine-protein kinase Chk1)

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anti-Checkpoint Kinase 1 (CHEK1) (pSer296) antibody
CHEK1 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated

anti-Checkpoint Kinase 1 (CHEK1) (pSer286) antibody
CHEK1 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated

anti-Checkpoint Kinase 1 (CHEK1) (pSer301) antibody
CHEK1 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated

anti-Checkpoint Kinase 1 (CHEK1) (pSer345) antibody
CHEK1 Reactivity: Human WB, IF, IHC (p), ICC Host: Rabbit Polyclonal unconjugated

anti-Checkpoint Kinase 1 (CHEK1) (Middle Region) antibody
CHEK1 Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig WB, IHC Host: Rabbit Polyclonal unconjugated

anti-Checkpoint Kinase 1 (CHEK1) (pSer317) antibody
CHEK1 Reactivity: Human WB, IHC (p), DB Host: Rabbit Polyclonal RB7845-RB18425 unconjugated

anti-Checkpoint Kinase 1 (CHEK1) antibody
CHEK1 Reactivity: Human, Mouse WB, ELISA Host: Mouse Monoclonal 2G1D5 unconjugated

anti-Checkpoint Kinase 1 (CHEK1) (pSer317) antibody
CHEK1 Reactivity: Mouse, Chicken ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated

anti-Checkpoint Kinase 1 (CHEK1) antibody
CHEK1 Reactivity: Human WB, ELISA, IHC, IF Host: Rabbit Monoclonal 2F2 unconjugated Recombinant Antibody

Application Notes

ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions

For Research Use only
Format

Liquid

Buffer

This antibody is stored in PBS, 50% glycerol

Preservative

Sodium azide

Precaution of Use

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage

-20 °C
Target

CHEK1 (Checkpoint Kinase 1 (CHEK1))

Alternative Name

CHEK1 (CHEK1 Products)

Background

CHEK1(Serine/threonine-protein kinase Chk1) involved in cell cycle arrest when dna damage has occurred or when unligated dna is present. CHEK1 binds to and phosphorylates CDC25A, CDC25B and CDC25C. The phosphorylation of CDC25C creates a binding site for 14-3-3 protein which inhibits CDC25C. This prevents activation of the CDC2-Cyclin B complex and prevents mitotic entry. The CHEK1 phosphorylates CDC25C on serine216. Chk1 plays a primary role in the protection of cells from death induced by replication fork stress, whereas p21 mediates through its role in regulating entry into S phase. Chk1 deficiency resulted in a premature onset of mitosis because of abnormal activation of cyclin B-Cdc2 and led to the activation of caspases 3 and 9 triggered by cytoplasmic release of cytochrome c. It belongs to the Ser/Thr family of protein kinases and NIM1 subfamily.

Pathways

p53 Signaling, Apoptosis, Cell Division Cycle, DNA Damage Repair