PCNA antibody (C-Term, ubLys164)

Catalog No. ABIN966812

The Rabbit Polyclonal anti-PCNA antibody has been validated for IHC. It is suitable to detect PCNA in samples from Human and Rat. There are 6+ publications available.

Quick Overview for PCNA antibody (C-Term, ubLys164) (ABIN966812)

Target: PCNA (Proliferating Cell Nuclear Antigen (PCNA))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCNA antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-PCNA Antibody

Binding Specificity: C-Term, ubLys164

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-residues of human PCNA (proliferating cell nuclear antigen)
Note: Antigen containing K164 amino group with the ubiquitin c-terminal 7-mer peptide bound: CLRLRGG

Application Details

Restrictions: For Research Use only

Handling

Storage: 4 °C

References for anti-PCNA antibody (ABIN966812)

Kweekel, Antonini, Nortier, Punt, Gelderblom, Guchelaar: "Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array." in: British journal of cancer, Vol. 101, Issue 2, pp. 357-62, (2009) (PubMed).

Niwa, Miwa, Kuzuya, Iwasaki, Haneda, Ueki, Katayama, Hiramitsu, Goto, Nagasaka, Watarai, Uchida, Nakao, Kobayashi: "Stimulation index for PCNA mRNA in peripheral blood as immune function monitoring after renal transplantation." in: Transplantation, Vol. 87, Issue 9, pp. 1411-4, (2009) (PubMed).

Michiels, Laplanche, Boulet, Dessen, Guillonneau, Méjean, Desgrandchamps, Lathrop, Sarasin, Benhamou: "Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk." in: Carcinogenesis, Vol. 30, Issue 5, pp. 763-8, (2009) (PubMed).

Canova, Hashibe, Simonato, Nelis, Metspalu, Lagiou, Trichopoulos, Ahrens, Pigeot, Merletti, Richiardi, Talamini, Barzan, Macfarlane, Macfarlane, Holcátová, Bencko, Benhamou, Bouchardy, Kjaerheim et al.: "Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project. ..." in: Cancer research, Vol. 69, Issue 7, pp. 2956-65, (2009) (PubMed).

Chen, Pan, Hurwitz: "Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 (replication factor C) of HeLa cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 7, pp. 2516-20, (1992) (PubMed).

Webb, Parsons, Chenevix-Trench: "Localization of the gene for human proliferating nuclear antigen/cyclin by in situ hybridization." in: Human genetics, Vol. 86, Issue 1, pp. 84-6, (1991) (PubMed).

Target Details for PCNA

Target: PCNA (Proliferating Cell Nuclear Antigen (PCNA))

Alternative Name: PCNA

Background: The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.

Pathways: Telomere Maintenance, DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Autophagy