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PCNA antibody (AA 53-196)
PCNA
Reactivity: Human
WB, IHC, ELISA, FACS
Host: Mouse
Monoclonal
7H4F8
unconjugated
Product Details anti-PCNA Antibody
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Target
See all PCNA Antibodies
PCNA
(Proliferating Cell Nuclear Antigen (PCNA))
Binding Specificity
All epitopes for PCNA antibodies
AA 53-196
Reactivity
All reactivities for PCNA antibodies
Human
Host
All hosts for PCNA antibodies
Mouse
Clonality
All clonalities for PCNA antibodies
Monoclonal
Conjugate
All conjugates for PCNA antibodies
This PCNA antibody is un-conjugated
Application
All applications for PCNA antibodies
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)
Purification
purified
Immunogen
Purified recombinant fragment of human PCNA (AA: 53-196 ) expressed in E. coli.
Clone
7H4F8
Isotype
IgG1
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Alternatives
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Application Details
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Application Notes
ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Purified antibody in PBS with 0.05 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C/-20 °C
Storage Comment
4°C, -20°C for long term storage
References for anti-PCNA antibody (ABIN1724760)
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Takawa, Cho, Hayami, Toyokawa, Kogure, Yamane, Iwai, Maejima, Ueda, Masuda, Dohmae, Field, Tsunoda, Kobayashi, Akasu, Sugiyama, Ohnuma, Atomi, Ponder, Nakamura, Hamamoto : "Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression. " in: Cancer research , Vol. 72 , Issue 13 , pp. 3217-27 , (2012 ) (PubMed ).
Zhao, Ho, Lo, Espejo, Bedford, Hung, Wang : "Interaction of proliferation cell nuclear antigen (PCNA) with c-Abl in cell proliferation and response to DNA damages in breast cancer. " in: PLoS ONE , Vol. 7 , Issue 1 , pp. e29416 , (2012 ) (PubMed ).
Target Details for PCNA
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Target
PCNA
(Proliferating Cell Nuclear Antigen (PCNA))
Alternative Name
PCNA (PCNA Products )
Synonyms
PCNAR antibody, Pcna/cyclin antibody, pcna antibody, AO090003000846 antibody, 53/13 antibody, CG9193 antibody, DmPCNA antibody, Dmel\\CG9193 antibody, MUS209 antibody, Mus209 antibody, PCNA antibody, PCNA/mus209 antibody, Pcna antibody, dPCNA antibody, l(2)02448 antibody, l(2)56F antibody, l(2)56Fa antibody, l(2)s1534 antibody, cb16 antibody, fb36g03 antibody, wu:fa28e03 antibody, wu:fb36g03 antibody, pcna-A antibody, proliferating cell nuclear antigen antibody, DNA polymerase III sliding clamp antibody, Proliferating cell nuclear antigen antibody, Proliferating cell nuclear antigen-like antibody, proliferating cell nuclear antigen L homeolog antibody, proliferating cell nuclear antigen 1 antibody, PCNA antibody, Pcna antibody, pcna antibody, MMP_RS08810 antibody, ANI_1_512014 antibody, AOR_1_1500154 antibody, MGC53867 antibody, pcna.L antibody, pcna1 antibody, LOC106420145 antibody, pcn1 antibody
Background
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. , ,
Molecular Weight
28.7 kDa
Gene ID
5111
HGNC
5111
Pathways
Telomere Maintenance , DNA Damage Repair , Mitotic G1-G1/S Phases , DNA Replication , Synthesis of DNA , Autophagy
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