SYNPO antibody (AA 495-509)

Catalog No. ABIN967124

Product Details anti-SYNPO Antibody

Target: SYNPO (Synaptopodin (SYNPO))

Binding Specificity: AA 495-509

Reactivity: Human, Rat

Host: Please inquire

Clonality: Polyclonal

Conjugate: This SYNPO antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Immunogen: A synthetic peptide corresponding to a sequence at the middle region of human synaptopodin (495-509 aa), identical to the related mouse and rat sequence.

Application Details

Restrictions: For Research Use only

Handling

Reconstitution: 0.2ml of distilled water will yield a concentration of 500µg/ml.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Preservative: Thimerosal (Merthiolate), Sodium azide

Storage: -20 °C

References for anti-SYNPO antibody (ABIN967124)

Cooney, Hurlburt, Selig, Harris, Fiala: "Endosomal compartments serve multiple hippocampal dendritic spines from a widespread rather than a local store of recycling membrane." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 6, pp. 2215-24, (2002) (PubMed).

Deller, Merten, Roth, Mundel, Frotscher: "Actin-associated protein synaptopodin in the rat hippocampal formation: localization in the spine neck and close association with the spine apparatus of principal neurons." in: The Journal of comparative neurology, Vol. 418, Issue 2, pp. 164-81, (2000) (PubMed).

GRAY: "Electron microscopy of synaptic contacts on dendrite spines of the cerebral cortex." in: Nature, Vol. 183, Issue 4675, pp. 1592-3, (1959) (PubMed).

Target Details for SYNPO

Target: SYNPO (Synaptopodin (SYNPO))

Alternative Name: Synaptopodin (SYNPO Products)

Synonyms: SYNPO antibody, DKFZp459N012 antibody, 9030217H17Rik antibody, 9130229N11 antibody, 9330140I15Rik antibody, AW046661 antibody, synaptopodin antibody, formin-like protein 5 antibody, SYNPO antibody, LOC100147046 antibody, Synpo antibody

Background: The spine apparatus (SA) is a specialized form of endoplasmic reticulum (ER) that is found in a subpopulation of dendritic spines in central neurons. The SA consists of a series of stacked discs that are thought to be connected to each other and to the dendritic system of ER-tubules. The actin binding protein synaptopodin (which has originally been described in podocytes of the kidney) is an essential component of the SA. Mice that lack the gene for synaptopodin do not form a spine apparatus. The SA is believed to play a critical role in learning and memory. In summary, an important function of the spine apparatus is the regulation of plasticity at individual synapses, a process known as metaplasticity. The International Radiation Hybrid Mapping Consortium mapped the SYNPO gene to chromosome 5.