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STAT4 antibody (AA 136-258)

STAT4 Reactivity: Mouse, Rat WB, IF Host: Mouse Monoclonal 8-Stat4 unconjugated
Catalog No. ABIN968254
  • Target See all STAT4 Antibodies
    STAT4 (Signal Transducer and Activator of Transcription 4 (STAT4))
    Binding Specificity
    • 33
    • 11
    • 8
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 136-258
    Reactivity
    • 88
    • 53
    • 35
    • 5
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    Mouse, Rat
    Host
    • 96
    • 6
    • 2
    • 2
    Mouse
    Clonality
    • 87
    • 19
    Monoclonal
    Conjugate
    • 54
    • 8
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This STAT4 antibody is un-conjugated
    Application
    • 78
    • 48
    • 41
    • 24
    • 22
    • 16
    • 13
    • 13
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Cross-Reactivity
    Rat (Rattus), Mouse (Murine)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human Stat4 aa. 136-258
    Clone
    8-Stat4
    Isotype
    IgG1
    Top Product
    Discover our top product STAT4 Primary Antibody
  • Comment

    Related Products: ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20° C.
  • Frank, Robertson, Bonni, Ritz, Greenberg: "Interleukin 2 signaling involves the phosphorylation of Stat proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 17, pp. 7779-83, (1995) (PubMed).

    Yamamoto, Quelle, Thierfelder, Kreider, Gilbert, Jenkins, Copeland, Silvennoinen, Ihle: "Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation." in: Molecular and cellular biology, Vol. 14, Issue 7, pp. 4342-9, (1994) (PubMed).

    Zhong, Wen, Darnell: "Stat3 and Stat4: members of the family of signal transducers and activators of transcription." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 11, pp. 4806-10, (1994) (PubMed).

  • Target
    STAT4 (Signal Transducer and Activator of Transcription 4 (STAT4))
    Alternative Name
    Stat4 (STAT4 Products)
    Synonyms
    SLEB11 antibody, signal transducer and activator of transcription 4 antibody, STAT4 antibody, stat4 antibody, Stat4 antibody
    Background
    The Stat proteins function as both cytoplasmic signal transducers and activators of transcription. Stat91/84 (the two proteins are the result of alternate splicing-Stat91 has an additional 38 C-terminal amino acids) and Stat113 were the first identified members of this protein family. With the discovery of additional members of the Stat family (Stat 3 & 4), the nomenclature has been revised to reflect the order of their discovery. Stat 91, 84, and 113 have become Stat1alpha, Stat1beta, and Stat2, respectively. Stat4 has been reported to be 52% identical to Stat1 and 47% identical to Stat3. Functionally, Stat4 is similar to the other Stat proteins in that it requires tyrosine phosphorylation in order to stimulate its IFN-gamma activated site (GAS) binding activity. Expression of Stat4 appears to be limited to thymus, spleen, and testis. Its expression in several myeloid cell lines is differentially regulated during cellular differentiation. Co-transfection studies using JAK1 or JAK2 expression constructs indicate that Stat4 is a substrate for these kinases.
    Synonyms: Signal Transducers and Activators of Transcription-4
    Molecular Weight
    89 kDa
    Pathways
    JAK-STAT Signaling
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