DDR1 antibody (AA 602-681)

Catalog No. ABIN969082

Product Details anti-DDR1 Antibody

Target: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Binding Specificity: AA 602-681

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DDR1 antibody is un-conjugated

Application: ELISA

Purpose: DDR1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of DDR1 (aa602-681) expressed in E. Coli.

Clone: 2G4E12

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-DDR1 antibody (ABIN969082)

Mohan, Mohan, Wilson: "Discoidin domain receptor (DDR) 1 and 2: collagen-activated tyrosine kinase receptors in the cornea." in: Experimental eye research, Vol. 72, Issue 1, pp. 87-92, (2001) (PubMed).

Foehr, Tatavos, Tanabe, Raffioni, Goetz, Dimarco, De Luca, Bradshaw: "Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 14, Issue 7, pp. 973-81, (2000) (PubMed).

Target Details for DDR1

Target: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Alternative Name: DDR1 (DDR1 Products)

Background: DDR1: discoidin domain receptor tyrosine kinase 1. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.

UniProt: Q08345

Pathways: RTK Signaling, Smooth Muscle Cell Migration