JAK3 antibody

Catalog No. ABIN969224

The Mouse Monoclonal anti-JAK3 antibody has been validated for WB, ELISA, FACS and ICC. It is suitable to detect JAK3 in samples from Human and Mouse. There is 1 publication available.

Quick Overview for JAK3 antibody (ABIN969224)

Target: JAK3 (Janus Kinase 3 (JAK3))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This JAK3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: 5H2

Product Details anti-JAK3 Antibody

Purpose: JAK3 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human JAK3 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-JAK3 antibody (ABIN969224)

Wood, Goodman, Uckun: "Jak3 expression and genomic sequence in pediatric acute lymphoblastic leukemia." in: Leukemia & lymphoma, Vol. 43, Issue 12, pp. 2355-62, (2003) (PubMed).

Target Details for JAK3

Target: JAK3 (Janus Kinase 3 (JAK3))

Alternative Name: JAK3

Background: JAK3, Janus kinase 3. It is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).

Molecular Weight: 125 kDa

Gene ID: 3718

UniProt: P52333

Pathways: JAK-STAT Signaling, RTK Signaling, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus, Activated T Cell Proliferation, Unfolded Protein Response