Lamin A/C antibody

Catalog No. ABIN969260

The Mouse Monoclonal anti-Lamin A/C antibody has been validated for WB, IHC and ELISA. It is suitable to detect Lamin A/C in samples from Human, Mouse and Rat. There is 1 publication available.

Quick Overview for Lamin A/C antibody (ABIN969260)

Target: Lamin A/C (LMNA)

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Lamin A/C antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 4E7

Product Details anti-Lamin A/C Antibody

Purpose: LMNA Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human LMNA expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Lamin A/C antibody (ABIN969260)

Carboni, Porcu, Mura, Cocco, Marrosu, Maioli, Solla, Tranquilli, Orrù, Marrosu: "Evolution of the phenotype in a family with an LMNA gene mutation presenting with isolated cardiac involvement." in: Muscle & nerve, Vol. 41, Issue 1, pp. 85-91, (2009) (PubMed).

Target Details for Lamin A/C

Target: Lamin A/C (LMNA)

Alternative Name: LMNA

Background: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

Molecular Weight: 74 kDa

UniProt: P02545

Pathways: Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus