FOXO1 antibody

Catalog No. ABIN969521

The Mouse Monoclonal anti-FOXO1 antibody has been validated for WB, IHC, ELISA and ICC. It is suitable to detect FOXO1 in samples from Human and Mouse. There are 2+ publications available.

Quick Overview for FOXO1 antibody (ABIN969521)

Target: FOXO1 (Forkhead Box O1 (FOXO1))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This FOXO1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC)

Clone: 3B6

Product Details anti-FOXO1 Antibody

Purpose: FOXO1 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human FOXO1 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-FOXO1 antibody (ABIN969521)

Lau, Koty, Nalbantoglu: "Differential response of glioma cells to FOXO1-directed therapy." in: Cancer research, Vol. 69, Issue 13, pp. 5433-40, (2009) (PubMed).

Srivastava, Yasruel, Nalbantoglu: "Impaired medulloblastoma cell survival following activation of the FOXO1 transcription factor." in: International journal of oncology, Vol. 35, Issue 5, pp. 1045-51, (2009) (PubMed).

Target Details for FOXO1

Target: FOXO1 (Forkhead Box O1 (FOXO1))

Alternative Name: FOXO1

Background: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined, however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.

Molecular Weight: 69.7 kDa

UniProt: Q12778

Pathways: PI3K-Akt Signaling, Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Carbohydrate Metabolic Process, CXCR4-mediated Signaling Events, BCR Signaling