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|Antigen||BCL2-Like 1 (BCL2L1) Antibodies|
|Epitope||AA 18-233 Alternatives|
|Reactivity||Chicken, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This BCL2L1 antibody is un-conjugated Alternatives|
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
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Product Details anti-BCL2L1 AntibodyTarget Details BCL2L1 Application Details Handling References for anti-BCL2L1 antibody (ABIN967828) Images
|Cross-Reactivity||Mouse (Murine), Chicken|
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
|Purification||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|Immunogen||Rat Bcl-xL aa. 18-233|
Target Details BCL2L1Product Details anti-BCL2L1 Antibody Application Details Handling References for anti-BCL2L1 antibody (ABIN967828) Images back to top
|Alternative Name||Bcl-x (BCL2L1 Antibody Abstract)|
|Background||Bcl-x is related to the Bcl-2 protein and can function independently of Bcl-2 in regulating apoptosis (programmed cell death). The bcl-x transcript is found in a number of tissues, with the highest levels in the lymphoid and central nervous systems. Two distinct cDNA species, bcl-xL and bcl-xS, have been observed and appear to arise from alternate 5' splice sites located within the first coding exon of the bcl-x gene. Bcl-xL is composed of 233 amino acids and is similar in size and structure to Bcl-2. Bcl-xS lacks 63 amino acids corresponding to the region of Bcl-xL with the highest degree of homology to Bcl-2. Like Bcl-2, Bcl-xL has been reported to inhibit cell death upon growth factor withdrawal in an IL-3-dependent cell line. However, Bcl-xS inhibits the ability of Bcl-2 to enhance cell survival in the absence of growth factors. This antibody is routinely tested by western blot analysis.|
|Molecular Weight||26 kDa|
|Pathways||Apoptosis, Negative Regulation of intrinsic apoptotic Signaling|
Application DetailsProduct Details anti-BCL2L1 Antibody Target Details BCL2L1 Handling References for anti-BCL2L1 antibody (ABIN967828) Images back to top
Related Products: ABIN968555, ABIN967389
|Restrictions||For Research Use only|
HandlingProduct Details anti-BCL2L1 Antibody Target Details BCL2L1 Application Details References for anti-BCL2L1 antibody (ABIN967828) Images back to top
|Buffer||Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store undiluted at -20° C.|
References for anti-BCL2L1 antibody (ABIN967828)Product Details anti-BCL2L1 Antibody Target Details BCL2L1 Application Details Handling Images back to top
|Product cited in:||
Kurowska, Rudnicka, Kontny, Janicka, Chorazy, Kowalczewski, Ziółkowska, Ferrari-Lacraz, Strom, Maśliński: "Fibroblast-like synoviocytes from rheumatoid arthritis patients express functional IL-15 receptor complex: endogenous IL-15 in autocrine fashion enhances cell proliferation and expression of Bcl-x(L) and Bcl-2." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 4, pp. 1760-7, 2002
Slupianek, Hoser, Majsterek, Bronisz, Malecki, Blasiak, Fishel, Skorski: "Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G(2)/M phase, and protection from apoptosis." in: Molecular and cellular biology, Vol. 22, Issue 12, pp. 4189-201, 2002
Rosen, Coll, Li, Filmus: "Transforming growth factor-alpha prevents detachment-induced inhibition of c-Src kinase activity, Bcl-XL down-regulation, and apoptosis of intestinal epithelial cells." in: The Journal of biological chemistry, Vol. 276, Issue 40, pp. 37273-9, 2001
Imaizumi, Morihara, Mori, Katayama, Tsuda, Furuyama, Wanaka, Takeda, Tohyama: "The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein." in: The Journal of biological chemistry, Vol. 274, Issue 12, pp. 7975-81, 1999
Anderson, Teutsch, Dong, Wortis: "An essential role for Bruton's [corrected] tyrosine kinase in the regulation of B-cell apoptosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 20, pp. 10966-71, 1996
ImagesProduct Details anti-BCL2L1 Antibody Target Details BCL2L1 Application Details Handling References for anti-BCL2L1 antibody (ABIN967828) back to top