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SARS-CoV-2 Spike Antibodies

The SARS-CoV-2 spike protein remains the central target for vaccines, therapeutic antibodies, and serological assays, but ongoing viral evolution has introduced significant mutations—especially within the RBD—that can alter antibody binding and reduce neutralization potency. As circulating variants continue to diverge from the original 2020 spike, reliance on early-generation reagents is no longer sufficient. For research, diagnostics, and vaccine development, updated spike constructs and antibodies that maintain activity across variant lineages—or are specifically tailored to current sequences—are increasingly essential.

Discover our selection of neutralizing antibodies!

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189 results

Recombinant SARS-CoV-2 Spike S1 antibody (RBD)

Reactivity: SARS Coronavirus-2 (SARS-CoV-2), SARS Coronavirus (SARS-CoV), SARS CoV-2 Alpha, SARS CoV-2 Beta, SARS CoV-2 Epsilon, SARS CoV-2 Gamma, SARS CoV-2 Eta, SARS CoV-2 Kappa, SARS CoV-2 Delta, SARS CoV-2 Omicron ELISA, Crys, SPR, IF Host: Human Monoclonal CR3022 unconjugated Recombinant Antibody

Multiplex Immunohistochemistry validation image for anti-SARS-CoV-2 Spike S1 (RBD) antibody (ABIN6952546)

Multiplex Immunohistochemistry validation image for anti-SARS-CoV-2 Spike S1 (RBD) antibody (ABIN6952546)

Binding curve of four different formats of anti-COVID-19 & SARS-CoV S glycoprotein antibody CR3022 (ABIN6952546) to SARS-CoV-2 Spike Glycoprotein domains S1 and S2 (His-Tag (Insect Cells)).

Binding curve of anti-COVID-19 & SARS-CoV S glycoprotein antibody CR3022 (ABIN6952546) to SARS-CoV-2 Spike Glycoprotein domains S1 and S2 of various origin.

Binding curve of anti-COVID-19 & SARS-CoV S glycoprotein antibody CR3022 (ABIN6952546) to SARS-CoV-2 Spike Glycoprotein (S1), Sheep Fc-Tag and SARS-CoV-2 Spike Glycoprotein (S2), Sheep Fc-Tag from HEK293 cells.

Binding curve of anti-COVID-19 & SARS-CoV S glycoprotein antibody CR3022 to SARS-CoV-2 Spike Glycoprotein domains S1 and S2 (His-Tag (Insect Cells)).

Biolayer interferometry was used to determine dissociation constants of SARS-BLOCK™ peptides associated with IgG neutralizing antibody (ABIN6952546).

Microscale thermophoresis measurement of binding of anti-SARS-CoV-2 Spike S1 antibody (RBD) CR3022 (ABIN6952546) to SARS-CoV-2 Spike (Trimer) protein (ABIN6952670).

Microscale thermophoresis measurement of binding of anti-SARS-CoV-2 Spike S1 antibody (RBD) CR3022 (ABIN6952546) to SARS-CoV-2 Spike (B.

Microscale thermophoresis measurement of binding of anti-SARS-CoV-2 Spike S1 antibody (RBD) CR3022 (ABIN6952546) to SARS-CoV-2 Spike (B.

Microscale thermophoresis measurement of binding of anti-SARS-CoV-2 Spike S1 antibody (RBD) CR3022 (ABIN6952546) to SARS-CoV-2 Spike (P.

Surface expression and recognition of minispike by COVID-19 patient serum.

VeroE6 cells infected over night with VSVDeltaG-minispike-eGFP (green) are recognized by IgG of S ELISA-positive patients in contrast to a control replicon expressing blue fluorescent protein (VSVDeltaG-BFP).

Microscale thermophoresis measurement of binding of anti-SARS-CoV-2 Spike S1 antibody (RBD) CR3022 (ABIN6952546) to SARS-CoV-2 Spike (B.

Microscale thermophoresis measurement of binding of anti-SARS-CoV-2 Spike S1 antibody (RBD) CR3022 (ABIN6952546) to SARS-CoV-2 Spike (B.

Mutations (indicated in orange) in the SARS-CoV-2 S Protein Receptor Binding Domain (RBD) in variants of concern (grey) and variants of note (mint).

Microscale thermophoresis measurement of binding of anti-SARS-CoV-2 Spike S1 antibody (RBD) CR3022 (ABIN6952546) to SARS-CoV-2 Spike (B.

17 images

8 references

Independent Validation

1 validation

Catalog No. ABIN6952546

Independently Validated

SARS-CoV-2 Spike antibody (C-Term)

Reactivity: SARS Coronavirus-2 (SARS-CoV-2), SARS Coronavirus (SARS-CoV) ELISA, WB, IF, IHC Host: Rabbit Polyclonal unconjugated

ELISA Test Antibodies: SARS-CoV-2 (COVID-19, 2019-nCoV) Spike antibody, ABIN1030641 (1 μg/mL).

Immunofluorescence Validation of SARS-CoV-2 (COVID-19) Spike in 293T Cells.

Immunohistochemical analysis of paraffin-embedded COVID-19 patient lung tissue using anti-SARS-CoV-2 (COVID-19) Spike S2 antibody (ABIN1030641, 0.

Immunohistochemical analysis of paraffin-embedded COVID-19 patient lung tissue using anti-SARS-CoV-2 (COVID-19) Spike S2 antibody (ABIN1030641, 0.

IHC/IF Validation in COVID-19 Patient Sample (Source: Nuovo et al.

IF Validation of SARS-CoV2 Spike in COVID-19 Patient Lung (Source: Magro et al.

IF Validation of SARS-CoV2 Spike in COVID-19 Patient Skin (Source: Magro et al.

IHC Validation of SARS-CoV2 Spike in the Nasopharyngeal Swab Sample of the COVID-19 Patient.

IHC Validation of SARS-CoV2 Spike in COVID-19 Patient Lung.

IHC Validation of SARS-CoV2 Spike in COVID-19 Patient Brain.

Overexpression Validation in Spike Transfected 293 Cells.

11 images

11 references

Catalog No. ABIN1030641

SARS-CoV-2 Spike antibody

Reactivity: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Alpha, SARS CoV-2 Beta, SARS CoV-2 Gamma ELISA, WB Host: Rabbit Polyclonal unconjugated

Direct ELISA of SARS-CoV-2 variant proteins with anti-SARS-CoV-2 Spike S1 antibody ABIN6952962.

Immunofluorescence Validation of SARS-CoV-2 (COVID-19) Spike (cleavage site) in 293 Transfected CellsImmunofluorescent analysis of 4 % paraformaldehyde-fixed Spike transfected 293cells labeling SARS-CoV-2 (COVID-19) Spike (cleavage site) with ABIN6952962 at 10 mg/mL, followed by goat anti-rabbit IgG secondary antibody at 1/500 dilution (green) and DAPI staining (blue).

Overexpression Validation in Spike Transfected 293 Cells Loading: 10 μg per lane of 293 cell lysate.

Western Blot Validation with SARS-CoV-2 (COVID-19) Spike S1 Recombinant Protein Loading: 50 ng per lane of SARS-CoV-2 (COVID-19) Spike S1 recombinant protein (97-087).

ELISA Validation with SARS-CoV-2 (COVID-19) Spike S1 Recombinant ProteinAntibodies: SARS-CoV-2 (COVID-19) Spike antibody (cleavage site), ABIN6952962 (1 μg/mL).

Western Blot Validation with SARS-CoV-2 (COVID-19) Spike Recombinant Protein Loading: 30 ng per lane of SARS-CoV-2 (COVID-19) Spike RBD+SD1+SD2 recombinant protein, 10-305.

ELISA Validation with SARS-CoV-2 (COVID-19) Spike Recombinant ProteinAntibodies: SARS-CoV-2 (COVID-19) Spike antibody (cleavage site), ABIN6952962.

ELISA Validation of SARS-CoV-2 Spike Antibody Pair A sandwich ELISA was performed using the anti-SARS-COV-2 Spike S1 antibodies ABIN6952962 (10 μg/mL ) as the capture antibody.

8 images

Catalog No. ABIN6952962

Recombinant SARS-CoV-2 Spike antibody (AA 319-541)

Animal-Free Reactivity: SARS Coronavirus-2 (SARS-CoV-2) ELISA, WB, FACS, IF Host: Mouse Monoclonal AB68-A09 unconjugated Recombinant Antibody

S1 Protein of different beta-corona strains were coated on an ELISA plate at 100 ng.

Calu-3 cells were infected with SARS-CoV-2 (B.

S1 Protein of different corona strain mutants (produced in Hi5 cells) were coated on an ELISA plate at 100 ng.

Sandwich ELISA assay with S1 protein of SARS-Cov-2.

4 images

Catalog No. ABIN7581775

Recombinant SARS-CoV-2 Spike S1 antibody (RBD)

Reactivity: SARS Coronavirus-2 (SARS-CoV-2), SARS Coronavirus (SARS-CoV), SARS CoV-2 Alpha, SARS CoV-2 Beta, SARS CoV-2 Epsilon, SARS CoV-2 Gamma, SARS CoV-2 Eta, SARS CoV-2 Kappa ELISA, Crys, SPR, IF Host: Rabbit Chimeric CR3022 unconjugated Recombinant Antibody

Binding curve of anti-COVID-19 & SARS-CoV S glycoprotein antibody CR3022 (ABIN6952546) to SARS-CoV-2 Spike Glycoprotein domains S1 and S2 of various origin.

Mutations (indicated in red) in the SARS-CoV-2 S Protein receptor binding domain (RBD, mint) in variants of concern (light grey) and variants of note (light mint).

Binding curve of anti-COVID-19 & SARS-CoV S glycoprotein antibody CR3022 (ABIN6952546) to SARS-CoV-2 Spike Glycoprotein (S1), Sheep Fc-Tag and SARS-CoV-2 Spike Glycoprotein (S2), Sheep Fc-Tag from HEK293 cells.

3 images

5 references

Catalog No. ABIN6952547

Recombinant SARS-CoV-2 Spike antibody (Receptor Binding Domain) (Fc Tag)

Reactivity: SARS Coronavirus-2 (SARS-CoV-2) ELISA, Neut, GICA Host: Human Monoclonal A1 Fc Tag single-domain Antibody (sdAb) Recombinant Antibody

The Binding Activity of SARS-CoV-2 Spike RBD Nanobody with SARS-CoV-2-S1-RBD.

GICA: In the Colloidal Gold Immunochromatography Assay detection system, the background of antibody (ABIN6953152) is clean, the detection limit can be as low as 25 ng/mL (1.

Activity: Binding signal of SARS-CoV-2 Spike RBD Nanobody (ABIN6953152) and SARS-CoV-2-S1-RBD (ABIN6953166) was inhibited by ACE2 protein-HRP conjugated inhibitor with the IC50 is 1.

Neutralizing Assay: Binding signal of SARS-CoV-2 Spike RBD Nanobody (ABIN6953152) and SARS-CoV-2-S1-RBD (ABIN6953166) was inhibited by ACE2 protein-HRP conjugated inhibitor with the IC50 is 0.

4 images

Catalog No. ABIN6953152

SARS-CoV-2 Spike S1 antibody

Reactivity: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Alpha, SARS CoV-2 Beta, SARS CoV-2 Epsilon, SARS CoV-2 Gamma ELISA, Neut Host: Human Chimeric AM122 unconjugated

Immobilized Human ACE2, His Tag (ABIN6952641) at 2 μg/mL (100 μL/well) can bind pre-mixed increasing concentrations of Anti-SARS-CoV-2 Neutralizing Antibody, Mouse IgG1 (ABIN6953206) and 0.

Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (ABIN6953206) on SDS-PAGE under reducing (R) and non-reducing (NR) conditions.

The purity of Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (AM122) (ABIN6953206) was more than 90% and the molecular weight of this protein is around 135-150 kDa verified by SEC-MALS.

Immobilized SARS-CoV-2 S1 protein, His Tag (ABIN6973257) at 2 μg/mL (100 μL/well) can bind Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (AM122) (ABIN6953206) with a linear range of 0.

Immobilized Anti-SARS-CoV-2 Spike S1 Antibody, chimeric mAb (ABIN6953206) at 2 μg/mL (100 μL/well) can bind S protein RBD.

5 images

Catalog No. ABIN6953206

SARS-CoV-2 Spike S2 antibody

Reactivity: SARS Coronavirus-2 (SARS-CoV-2) WB, IF Host: Rabbit Monoclonal unconjugated

Western blot analysis of extracts of normal 293T cells and 293T transfected with Nucleoprotein Protein, using SARS-CoV-2 Nucleoprotein antibody (ABIN7269052) at 1:10000 dilution.

Immunofluorescence analysis of 293T-N and 293T cells using SARS-CoV-2 Nucleoprotein Rabbit mAb (ABIN7269052) at dilution of 1:100,1:400,1:1600,1:3200 (40x lens).

2 images

Catalog No. ABIN7269052

Recombinant SARS-CoV-2 Spike antibody (AA 16-685) (Fc Tag,HRP)

Reactivity: SARS Coronavirus-2 (SARS-CoV-2) ELISA Host: Mouse Monoclonal H6 Fc Tag,HRP scFv fragment Recombinant Antibody

The Binding Activity of SARS-CoV-2-S Antibody, HRP conjugated with SARS-CoV-2-S.

1 image

1 reference

Catalog No. ABIN6953153

Recombinant SARS-CoV-2 Spike antibody (AA 319-541)

Reactivity: SARS Coronavirus-2 (SARS-CoV-2) ELISA, FACS Host: Rabbit Monoclonal DM54 unconjugated Recombinant Antibody

Elisa plate pre-coated by 2 μg/mL (100 μL/well) SARS-CoV-2 RBD protein can bind Rabbit Anti-SARS-CoV-2 RBD monoclonal antibody (clone:DM54) in a linear range of 0.

Competition flow cytometry assay demonstrating Rabbit anti-RBD monoclonal antibody (clone: DM54) blockade of SARS-CoV-2 (COVID-19) S protein RBD (1 μg/mL, ABIN6961175, ABIN7042379 and ABIN7042380) binding to Expi 293 cell line transfected with human .

2 images

Catalog No. ABIN6964062

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