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Cathepsin B Proteins

(Cathepsin B (CTSB))
The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

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  • Target: Cathepsin B (CTSB)
  • Protein
Catalog no. Product Reactivity Host / Clonality Application Price & lead time
ABIN7819933
Cathepsin B Protein (CTSB) (AA 51-339) (His tag) CTSB · Protein Mouse Bacteria
$500.50 View price
  • 100 μg
Delivery in 7 to 10 Business Days Shipping to: United States
Protein
Origin
Mouse
Host
Bacteria
Protein Type
Recombinant
Catalog No. ABIN7819933
$500.50
Plus shipping costs $50.00, if applicable $20.00 dry ice
100 μg
Shipping to: United States
Delivery in 7 to 10 Business Days

Latest Publications for our Cathepsin B Proteins

Hartmann, Lopez Cruz, Alameh, Ho, Rabideau, Pentelute, Bradley, Martchenko: "Characterization of Novel Piperidine-Based Inhibitor of Cathepsin B-Dependent Bacterial Toxins and Viruses." in: ACS infectious diseases, Vol. 4, Issue 8, pp. 1235-1245, (2018) (PubMed).

Peng, Zhang, Zheng, Liang, Li, Chen, Guo, Yoshina, Chen, Zhao, Wu, Liu, Mitani, Yu, Xue: "Cysteine protease cathepsin B mediates radiation-induced bystander effects." in: Nature, Vol. 547, Issue 7664, pp. 458-462, (2017) (PubMed).

Zilbermintz, Leonardi, Jeong, Sjodt, McComb, Ho, Retterer, Gharaibeh, Zamani, Soloveva, Bavari, Levitin, West, Bradley, Clubb, Cohen, Gupta, Martchenko: "Identification of agents effective against multiple toxins and viruses by host-oriented cell targeting." in: Scientific reports, Vol. 5, pp. 13476, (2015) (PubMed).

Chowdhury, Moya, Bhilocha, McMillan, Vigliarolo, Zehbe, Phenix: "Prodrug-inspired probes selective to cathepsin B over other cysteine cathepsins." in: Journal of medicinal chemistry, Vol. 57, Issue 14, pp. 6092-104, (2014) (PubMed).

Zhao, Hua, Crowley, Ru, Ni, Shaw, Jiao, Ding, Qu, Hung, Huang, Liu, Ye, Ouyang, Cheng, Liu: "Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage." in: Cell research, Vol. 24, Issue 3, pp. 344-58, (2014) (PubMed).

Cao, Taggart, Berquin, Moin, Fong, Sloane: "Human gastric adenocarcinoma cathepsin B: isolation and sequencing of full-length cDNAs and polymorphisms of the gene." in: Gene, Vol. 139, Issue 2, pp. 163-9, (1994) (PubMed).

Chan, San Segundo, McCormick, Steiner: "Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 20, pp. 7721-5, (1986) (PubMed).

Aliases for Cathepsin B Proteins

cathepsin B (CTSB) Proteins
cathepsin B (Ctsb) Proteins
cathepsin B S homeolog (ctsb.S) Proteins
cathepsin B (LOC692390) Proteins
APPS Proteins
apps Proteins
CB Proteins
CPSB Proteins
cpsb Proteins
CTSB Proteins
LOC692390 Proteins
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