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Cow (Bovine) Polyclonal NOX4 Primary Antibody for ICC, IHC (fro) - ABIN189715
Maranchie, Zhan: Nox4 is critical for hypoxia-inducible factor 2-alpha transcriptional activity in von Hippel-Lindau-deficient renal cell carcinoma. in Cancer research 2005
Show all 48 Pubmed References
Human Polyclonal NOX4 Primary Antibody for FACS, ICC - ABIN4340462
Weyemi, Caillou, Talbot, Ameziane-El-Hassani, Lacroix, Lagent-Chevallier, Al Ghuzlan, Roos, Bidart, Virion, Schlumberger, Dupuy: Intracellular expression of reactive oxygen species-generating NADPH oxidase NOX4 in normal and cancer thyroid tissues. in Endocrine-related cancer 2010
Show all 34 Pubmed References
Human Polyclonal NOX4 Primary Antibody for IHC, IHC (p) - ABIN409683
Zhang, Liu, Hu: Inhibiting cancer metastasis via targeting NAPDH oxidase 4. in Biochemical pharmacology 2013
Dog (Canine) Polyclonal NOX4 Primary Antibody for IF (p), IHC (p) - ABIN737526
Khan, Byer, Khan: Exposure of Madin-Darby canine kidney (MDCK) cells to oxalate and calcium oxalate crystals activates nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase. in Urology 2014
Human Polyclonal NOX4 Primary Antibody for IF (p), IHC (p) - ABIN702610
Kashiwabara, Ambe, Nakagawa, Watanabe: Immunohistochemical localization of Nox in mouse circumvallate papillae. in Tissue & cell 2015
The results establish a link between BRAF (show BRAF Antibodies)(V600E) and NOX4, which is confirmed by a comparative analysis of NOX4 expression in human (TCGA) and mouse thyroid cancers.
This study also showed that UCH-L1 (show UCHL1 Antibodies) promotes angiogenesis of HUVECs, as well as invasion in cancer cells, by up-regulating ROS (show ROS1 Antibodies) by deubiquitination of NOX4, suggesting that UCH-L1 (show UCHL1 Antibodies) plays a key role in angiogenesis of HUVECS by regulating ROS (show ROS1 Antibodies) levels by deubiquitination of NOX4.
The results reveal that NOX4 promotes glycolysis, contributing to non-small cell lung cancer cells growth, and supports glutaminolysis for oxidative resistance.
Metformin attenuates idiopathic lung fibrosis development via suppression of myofibroblast NOX4 expression.
Letter: airway smooth muscle cell NOX4 expression is increased in vivo and in vitro in COPD (show ARCN1 Antibodies).
TIS21 (show BTG2 Antibodies) attenuated Doxorubicin-induced cancer cell senescence by inhibiting linear actin nucleation via Nox4-ROS (show ROS1 Antibodies)-ABI2 (show ABI2 Antibodies)-DRF (show MPO Antibodies) signal cascade
These results are consistent with the hypothesis that antioxidants or NOX1 (show NOX1 Antibodies)/4 inhibition may be useful in blocking profibrotic effects of TGFbeta (show TGFB1 Antibodies) on dermal and gingival fibroblasts and warrant consideration for further development as potential antifibrotic agents
These data suggested that t-BHP induced both apoptosis and necroptosis in endothelial cells which was mediated by ROS (show ROS1 Antibodies) and p38MAPK (show MAPK14 Antibodies). ROS (show ROS1 Antibodies) derived from NADPH oxidase (show NOX1 Antibodies) and mitochondria contributed to t-BHPL and t-BHPH-induced apoptosis and necroptosis, respectively
Brd4 (show BRD4 Antibodies) inhibition attenuates unilateral ureteral obstruction-induced fibrosis by blocking TGF-beta (show TGFB1 Antibodies)-mediated Nox4 expression.
We demonstrated that rapid deletion of p22phox (show CYBA Antibodies) is possible and that the activity of Nox1 (show NOX1 Antibodies) and Nox4 but not Nox5 (show NOX5 Antibodies) exclusively depends on p22phox (show CYBA Antibodies).
Strong dityrosine formation was observed, but was significantly weaker in NOX4-/- mice (p<0.05). NOX2 (show CYBB Antibodies), HIF1alpha (show HIF1A Antibodies) and CD31 (show PECAM1 Antibodies) expression was significantly weaker in NOX4-/- mice (p<0.05). In this study we show for the first time that NOX4 plays a role in cutaneous wound repair.
These results indicated that carnosic acid (CA)attenuated oxidative stress via inhibition of Nox4 expression in TGF-beta (show TGFB1 Antibodies)-stimulated fibroblasts and UUO operated-kidneys, suggesting that CA may be useful for the treatment of fibrosis-related diseases
Spinal cord injury leads to a significant increase in NOX4 expression.
NOX4 actively regulates smooth muscle cells (SMC (show DYM Antibodies)) pathophysiological responses in diabetic Apoe (show APOE Antibodies)(-/-) mice and in primary mouse SMCs through the activities of PDGF (show PDGFA Antibodies) and NOX1 (show NOX1 Antibodies).
we used the Ang II (show AGT Antibodies) infused hph-1 (show EGLN2 Antibodies) mice to examine the roles of NOX isoforms in the development of AAA (show AAAS Antibodies). We generated double mutants of hph-1 (show EGLN2 Antibodies)-NOX1 (show NOX1 Antibodies), hph-1 (show EGLN2 Antibodies)-NOX2 (show CYBB Antibodies), hph-1 (show EGLN2 Antibodies)-p47phox, and hph-1 (show EGLN2 Antibodies)-NOX4
The major reactive oxygen species (ROS (show ROS1 Antibodies)) source in brain, NADPH oxidase (show NOX1 Antibodies) subunit 4 increased in hypoxia but not in hyperoxia, whereas neither affected nuclear factor (erythroid-derived 2)-like 2 (show NFE2L2 Antibodies), a transcription factor that regulates the expression of antioxidant proteins
Nox4 has no influence on lifespan of healthy mice.
MFA has a protective effect on alcohol-induced liver injury, which may be related to its antioxidant,anti-inflammatory,lipid-eliminating properties and its ability to regulate the NOX4/ROS (show ROS1 Antibodies)-MAPK (show MAPK1 Antibodies) signalling pathway.
Peroxide derived from superoxide generated by Nox4 appears to maintain a basal relaxation in bovine pulmonary arteries under normoxic conditions, which is removed under hypoxia leading to hypoxic pulmonary vasoconstriction.
MRTF down-regulation/inhibition suppresses TGFbeta (show TGFB1 Antibodies)/contact disruption-provoked Nox4 protein and mRNA expression, Nox4 promoter activation, and reactive oxygen species production.
Nox4 NADPH oxidase (show NOX1 Antibodies) mediates oxidative stress and apoptosis caused by TNF-alpha (show TNF Antibodies) in cerebral vascular endothelial cells.
Nox4 NADPH oxidase (show NOX1 Antibodies)-derived reactive oxygen species also initiate a cell survival mechanism by increasing production of carbon monoxide by constitutive heme oxygenase-2 (show HMOX2 Antibodies).
proteasome inhibition completely prevented endoplasmic reticulum stress-induced increase in NADPH oxidase (show NOX1 Antibodies) activity, as well as increases in Nox4 isoform and protein disulfide isomerase (show P4HB Antibodies) mRNA expression
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.
PAF acetylhydrolase 30 kDa subunit
, PAF-AH 30 kDa subunit
, PAF-AH subunit beta
, PAF-AH1b alpha 2 subunit
, PAFAH subunit beta
, intracellular platelet-activating factor acetylhydrolase alpha 2 subunit
, platelet-activating factor acetylhydrolase IB subunit beta
, platelet-activating factor acetylhydrolase, isoform Ib, subunit 2 (30kDa)
, kidney oxidase-1
, kidney superoxide-producing NADPH oxidase
, renal NAD(P)H-oxidase
, superoxide-generating NADPH oxidase 4
, NADPH oxidase 4
, predicted NADPH oxidase-4