Browse our TFAP2A Proteins (TFAP2A)

Human Transcription Factor AP-2 alpha (Activating Enhancer Binding Protein 2 Alpha) (TFAP2A) interaction partners

1. The data suggest that IRF6 (show IRF6 Proteins), TFAP2A, and GRHL3 (show GRHL3 Proteins), among others, are shared in neural tube and orofacial development.

2. Results show that gout-associated increased NRBP1 (show NRBP1 Proteins) expression is regulated through methylation-dependent TFAP2A binding to the B1 region, which might be involved in the pathogenesis of gout.

3. our results indicate that AP-2alpha can reverse the Multidrug resistance (MDR) of gastric cancer cells, which may be realized by inhibiting the Notch (show NOTCH1 Proteins) signaling pathway.

4. High-confidence AP2alpha (show AP2A1 Proteins)-binding peaks were detected in the regulatory regions of many target genes involved in the development of facial tissues including MSX1 (show MSX1 Proteins), IRF6 (show IRF6 Proteins), TBX22 (show TBX22 Proteins), and MAFB (show MAFB Proteins). In addition, we uncovered multiple single-nucleotide polymorphisms (SNPs) disrupting a conserved AP2alpha (show AP2A1 Proteins) consensus sequence.

5. We identified two SLN genes (PIGR and TFAP2A) that provided high prognostic accuracy in SLN-positive melanoma patients (AUC = 0.864). These two SLN genes, along with clinicopathological features, can differentiate the high- and low-risk groups in node-positive melanoma patients

6. We identified miR (show MLXIP Proteins)-1254 as a negative regulator inhibiting HO-1 (show HMOX1 Proteins) translation by directly targeting HO-1 (show HMOX1 Proteins) 3'UTR via its seed region, and suppressing HO-1 (show HMOX1 Proteins) transcription via non-seed region-dependent inhibition of transcriptional factor AP-2 alpha (TFAP2A), a transcriptional activator of HO-1 (show HMOX1 Proteins).

7. dimerization-defective mutant of Nef failed to interact with either CD4 (show CD4 Proteins) or AP-2 (show GTF3A Proteins) in the BiFC assay, indicating that Nef quaternary structure is required for CD4 (show CD4 Proteins) and AP-2 (show GTF3A Proteins) recruitment as well as CD4 (show CD4 Proteins) down-regulation

8. Data show that TFAP2A binds many of the same regulatory elements as MITF (show MITF Proteins) in melanocytes.

9. the atrial fibrillation (AF)-associated SNP rs2595104 altered PITX2c (show PITX2 Proteins) expression via interaction with TFAP2a; such a pathway could ultimately contribute to AF susceptibility at the PITX2 (show PITX2 Proteins) locus associated with AF

10. AP-2a is an important transcription factor of DEK (show DEK Proteins) expression, which is correlated with the methylation level of the DEK (show DEK Proteins) core promoter in hepatocellular carcinoma .

Zebrafish Transcription Factor AP-2 alpha (Activating Enhancer Binding Protein 2 Alpha) (TFAP2A) interaction partners

1. Genetic interaction between tfap2a and mitfa suggest that the factors en (show MITF Proteins)coded by these genes regulate shared targets in melanocytes, possibly within single or converging pathways.

2. these data support a model in which Tfap2a, acting through Bmp7a (show BMP7 Proteins), modulates Fgf and Notch (show NOTCH1 Proteins) signaling to control the duration, amount and speed of SAG (show SAG Proteins) neural development.

3. Prdm1a directly binds and activates a tfap2a enhancer at the NPB

4. Low Bmp activates expression of the transcription factor Tfap2a as part of a gene regulatory network that coordinates development of neural crest, preplacodal ectoderm and individual placodes in zebrafish.

5. tfap2a and foxd3 (show FOXD3 Proteins) are expressed during gastrulation prior to neural crest induction in distinct, complementary, domains; tfap2a is expressed in the ventral non-neural ectoderm and foxd3 (show FOXD3 Proteins) in the dorsal mesendoderm and ectoderm

6. These results reveal that mutations in TFAP2A are associated with a wide range of eye phenotypes and that hypomorphic tfap2a mutations can increase the risk of developmental defects arising from mutations at other loci.

7. These findings reveal that Tfap2 activity, mediated redundantly by Tfap2a and Tfap2e (show TFAP2E Proteins), promotes melanophore differentiation in parallel with Mitf (show MITF Proteins) by an effector other than Kit.

8. Results demonstrate that tfap2a is required for early steps in neural crest development and for the survival of a subset of neural crest derivatives.

9. data show that hindbrain noradrenergic neurons of the locus coeruleus and the posterior groups both require Tfap2a to establish their noradrenergic identity

10. Ap-2alpha regulates multiple steps of melanophore development, and is required for development of other neuronal and non-neuronal neural crest derivatives.

Xenopus laevis Transcription Factor AP-2 alpha (Activating Enhancer Binding Protein 2 Alpha) (TFAP2A) interaction partners

1. Here, the authors show that adam13 (show ADAM33 Proteins) interacts with the arid3a/dril1 (show ARID3A Proteins)/Bright transcription factor. This interaction promotes a proteolytic cleavage of arid3a (show ARID3A Proteins) and its translocation to the nucleus where it regulates another transcription factor: tfap2alpha. Tfap2alpha in turn activates multiple genes including the protocadherin pcdh8l (PCNS).

2. AP2a initiates neural border patterning and is sufficient to elicit a neural border-like pattern in neuralized (show NEURL Proteins) ectoderm.

Cow (Bovine) Transcription Factor AP-2 alpha (Activating Enhancer Binding Protein 2 Alpha) (TFAP2A) interaction partners

Mouse (Murine) Transcription Factor AP-2 alpha (Activating Enhancer Binding Protein 2 Alpha) (TFAP2A) interaction partners

1. AP2gamma is present in a sub-population of hippocampal transient amplifying progenitors. There, it is found to act as a positive regulator of the cell fate determinants Tbr2 and NeuroD, promoting proliferation and differentiation of new glutamatergic granular neurons. Conditional ablation of AP2gamma in adult brain reduced hippocampal neurogenesis and disrupted coherence between ventral hippocampus and medial prefronta...

2. these findings reveal that the AP-2 genes have a major function in mammalian neural crest development, influencing patterning of the craniofacial skeleton

3. RNA interference of transcriptional factor activator protein 2alpha (AP-2alpha) reversed the inhibitory effects of aspirin on atherosclerosis in Apoe (show APOE Proteins)-/- mice.

4. Study systematically examined the expression profile of AP-2 family in the developing mouse and chick spinal cord and found that AP-2alpha and AP-2beta (show TFAP2B Proteins) are specifically expressed in post-mitotic dorsal interneurons. Subsequent functional assessment in chick embryos demonstrated that AP-2alpha and AP-2beta (show TFAP2B Proteins) have distinct functions in dorsal interneuron specification and differentiation.

5. MEX3C (show MEX3C Proteins) associates with the endolysosomal compartment through an endocytosis-like process. siRNA-mediated inhibition of the MEX3C (show MEX3C Proteins) or AP-2 complex (show AP2B1 Proteins) substantially decreased exosomal but not cellular microRNA miR (show MLXIP Proteins)-451a expression

6. High AP-2 alpha phosphorylation is associated with abdominal aortic aneurysm.

7. overexpression of Dnmt3a (show DNMT3A Proteins) partially rescued the impairment of adipogenesis induced by AP2alpha knockdown.

8. Data show that TFAP2A binds many of the same regulatory elements as MITF (show MITF Proteins) in melanocytes.

9. TFAP2A is a conserved component of the core network that regulates EMT (show ITK Proteins), acting as a repressor of many genes, including ZEB2 (show ZEB2 Proteins).

10. The AP-2beta (show TFAP2B Proteins) transcription factor is an important effector of PITX2 (show PITX2 Proteins) function during corneal development, required for differentiation of corneal endothelium and establishment of angiogenic privilege.