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CLDN6 (show CLDN6 Antibodies) enhances the chemoresistance to ADM (show ADM Antibodies) via activating the AF-6/ERK (show EPHB2 Antibodies) signaling pathway and up-regulating cancer stem cell characters in MDAMB231 cells.
AF6 employs a non-canonical, evolutionarily conserved alpha-helix to bind RAS, unique to AF6 and the classical RASSF effectors.
miR (show MLXIP Antibodies)-188-3p is a novel independent prognostic factor in colorectal cancer patients, which can be partly explained by its effect on MLLT4 expression and migration of cancer cells.
Afadin (AFDN), a cytoskeletal and junction-associated protein, was present in 2D and 3D keratinocyte cultures, and validated as a so-far-unknown EphA2 (show EPHA2 Antibodies)-interacting protein.
In pancreatic cancer cells, AF6 is expressed at reduced levels, causing Dvl2 (show DVL2 Antibodies) to be upregulated and available to bind and enhance FOXE1 (show FOXE1 Antibodies)-induced trans-activation of Snail (show SNAI1 Antibodies), which promotes proliferation and metastasis.
AF-6/afadin could be a useful selection marker for fertility-sparing therapy for patients with atypical hyperplasia or grade 1 endometrioid adenocarcinoma with no myometrial invasion.
JAM-A (show F11R Antibodies) regulates epithelial permeability via association with ZO-2 (show TJP2 Antibodies), afadin, and PDZ-GEF1 (show RAPGEF2 Antibodies) to activate Rap2c (show RAP2C Antibodies) and control contraction of the apical cytoskeleton.
MLL (show MLL Antibodies)-AF6 oncoprotein potentiates the activity of the RAS pathway through retention of AF6 within the nucleus.
The expression levels of CFTR (show CFTR Antibodies) and AF-6/afadin are significantly downregulated in human colon cancer tissues.
AF-6 is a positive modulator of the PINK1 (show PINK1 Antibodies)/parkin (show PARK2 Antibodies) pathway and is deficient in Parkinson's disease.
These results indicate that afadin plays multiple roles in the complex ultrastructural morphogenesis of hippocampal mossy fiber synapses.
Findings indicate that afadin plays an essential role in regulating apical-basal polarity and adherens junction integrity of radial glial cells.
Codepletion of the actomyosin regulator RhoA (show RHOA Antibodies) and Afadin results in defects in the central lumens and arrests lumen remodeling
Glutamate (show GRIN1 Antibodies) release and the postsynaptic responsiveness to glutamate (show GRIN1 Antibodies) were markedly reduced, but not completely lost, in the afadin-deficient mossy fiber synapse, whereas neither long-term potentiation nor long-term depression was affected.
Afadin regulates the differentiation of the CA3 (show CA3 Antibodies) pyramidal cells, elongation of the mossy fiber trajectory and the density of mossy fiber synapses.
afadin determines lumen placement by directing apical-basal spindle orientation, resulting in a continuous lumen and normal tubule morphogenesis.
Results indicate that afadin is required for the maintenance of the radial glial scaffold for neuronal migration and that the genetic ablation of afadin leads to the formation of double cortex
Here, the first crystal structure of the AFPDZ in complex with the nectin-3 (show PVRL3 Antibodies) C-terminal peptide containing the class II motif is reported.
Afadin plays a role in the restricted localization of Paneth cells at the base of the crypt by maintaining their adhesion to adjacent crypt cells and inhibiting their movement toward the top of villi.
S-afadin-specific C-terminal inserts may be involved in its preference of binding to nectin-3 (show PVRL3 Antibodies) and raise the possibility that there are proteins other than nectins that more preferentially bind s-afadin than l-afadin.
This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6\;11)(q27\;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
, ALL1-fused gene from chromosome 6 protein
, protein AF-6
, myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog
, protein Af-6
, myeloid/lymphoid or mixed-lineage leukemia 4