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Aurora-C interactions with members of the Chromosome Passenger Complex (CPC), Survivin (show BIRC5 Proteins) and Inner Centromere Protein (INCENP (show INCENP Proteins)) in reference to known Aurora-B (show AURKB Proteins) interactions to understand the functional significance of Aurora-C overexpression in human cancer cells, is reported.
Patients presenting with a monomorphic teratozoospermia such as globozoospermia or macrospermia with more than 85% of the spermatozoa presenting this specific abnormality have been analyzed permitting to identify several key genes for spermatogenesis such as AURKC and DPY19L2 (show DPY19L2 Proteins).
Homozygous c.144delC mutation in AURKC gene in infertile men with macrozoospermia in the Tunisian population
AURKC mutations are more frequent than Klinefelter syndrome and constitute the leading genetic cause of infertility in North African men.
Low AURKC expression is associated with cancer.
Overexpression of AURKC is associated with breast tumors.
Data indicate that the selective Aurora A (show AURKA Proteins), B, and C inhibitor SAR156497 showed antineoplastic activity in HCT116 cell xenograft model.
This review will describe the functions of each Aurora kinase (show AURKA Proteins) which include Aurora A (AURKA (show AURKA Proteins)), Aurora B (AURKB (show AURKB Proteins)) and Aurora C (AURKC summarize their involvement in leukemia and discuss inhibitor development and efficacy in leukemia clinical trials
Aberrantly expressed Aurora-C in somatic cancer cells may impair spindle checkpoint assembly by displacing the centromeric localization of chromosomal passenger complexes.
Our data indicate that the AURKC c.144delC mutation has a relatively high carrier frequency in the Moroccan population.
The high sequence similarity among the AURK family members has made discerning the individual kinase functions in meiosis challenging. Technical limitations in specifically targeting AURKB (show AURKB Proteins) or AURKC using small-molecule inhibitors and compensatory abilities in single-knockout animals add to this challenge...proper regulation of AURKA (show AURKA Proteins) expression is crucial for spindle formation in meiosis
Three of these mutations AURKC c.144delC (AURKC p.L49Wfs22), AURKC c.686G > A (AURKC p.C229Y) and AURKC c.744C > G (AURKC p.Y248*) are the focus of this study. AURKC p.L49Wfs22 is a loss-of-function mutant that perturbs localization of the chromosomal passenger complex (CPC), AURKC p.C229Y is a hypomorph that cannot fully support cell-cycle progression, and AURKC p.Y248* fails to support chromosome segregation.
These data uncover a role for haspin (show GSG2 Proteins) as a regulator of bipolar spindle assembly by regulating AURKC function at acentriolar microtubule-organizing centers in oocytes.
these data suggest that mammalian oocytes contain AURKC to efficiently execute meiosis I and ensure high-quality eggs necessary for sexual reproduction.
These findings suggest a model for the presence of AURKC in oocytes: that AURKC compensates for loss of AURKB (show AURKB Proteins) through differences in both message recruitment and protein stability.
Overexpressed Aurora-C (aurkc) is an oncogene (show RAB1A Proteins). Overexpression of Aurora-C induces abnormal cell division resulting in centrosome amplification and multinucleation. Cells overexpressing active Aurora-C induced tumour formation.
Conditional deletion of aurora B in somatic cells that do not express aurora C results in chromosomal misalignment and lack of chromosome segregation.
Aurora-C, but not Aurora-B, plays essential roles in female mouse meiosis.
role in regulating the cleavage furrow-specific vimentin (show VIM Proteins) phosphorylation in the cytokinetic process
INCENP (show INCENP Proteins) recruits Aurora-C (or some other factor(s) recruit INCENP (show INCENP Proteins) and Aurora-C) to meiotic chromosomes, while Aurora-C may either work alone or cooperate with Aurora-B to regulate chromosome segregation during male meiosis
AURKB (show AURKB Proteins), AURKC, and Thr (show TRH Proteins)-phosphorylated AURKA (show AURKA Proteins) were detected at a contractile ring/midbody during the first polar body extrusion.
This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.
aurora kinase C
, aurora 3
, aurora-related kinase 3
, aurora/IPL1-related kinase 3
, aurora/IPL1/EG2 protein 2
, serine/threonine kinase 13 (aurora/IPL1-like)
, serine/threonine-protein kinase 13
, serine/threonine-protein kinase aurora-C
, aurora B
, aurora/Ipl1/Eg2 protein 1
, serine/threonine kinase 13 (aurora/IPL-like)