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CTNS Products

(Cystinosis, Nephropathic (CTNS))

Categories

This gene encodes a seven-transmembrane domain protein that functions to transport cystine out of lysosomes. Its activity is driven by the H+ electrochemical gradient of the lysosomal membrane. Mutations in this gene cause cystinosis, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009].

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Featured CTNS Categories

CTNS Antibodies

High quality antibodies with extensive validation data.

CTNS ELISA Kits

Reliable ELISA kits for a wide range of species.

CTNS Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CTNS Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
  • (6)
Cat. No. ABIN560527
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
  • (2)
Cat. No. ABIN514757
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (5)
  • (1)
Cat. No. ABIN1881240
Quantity 400 μL
Datasheet Datasheet

Recommended CTNS ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1128563
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1128564
Quantity 96 tests
Datasheet Datasheet
Reactivity Cow
Analytical Method
Validations
Cat. No. ABIN1128562
Quantity 96 tests
Datasheet Datasheet

Recommended CTNS Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1350683
Quantity 2 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1350684
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7386026
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our CTNS products

McEvoy, Sumayao, Slattery, McMorrow, Newsholme: "Cystine accumulation attenuates insulin release from the pancreatic β-cell due to elevated oxidative stress and decreased ATP levels." in: The Journal of physiology, Vol. 593, Issue 23, pp. 5167-82, (2015) (PubMed).

Sumayao, McEvoy, Martin-Martin, McMorrow, Newsholme: "Cystine dimethylester loading promotes oxidative stress and a reduction in ATP independent of lysosomal cystine accumulation in a human proximal tubular epithelial cell line." in: Experimental physiology, Vol. 98, Issue 10, pp. 1505-17, (2013) (PubMed).

Bellomo, Corallini, Pastore, Palma, Laurenzi, Emma, Taranta: "Modulation of CTNS gene expression by intracellular thiols." in: Free radical biology & medicine, Vol. 48, Issue 7, pp. 865-72, (2010) (PubMed).

Taranta, Wilmer, van den Heuvel, Bencivenga, Bellomo, Levtchenko, Emma: "Analysis of CTNS gene transcripts in nephropathic cystinosis." in: Pediatric nephrology (Berlin, Germany), Vol. 25, Issue 7, pp. 1263-7, (2010) (PubMed).

Kumar, Bachhawat: "A futile cycle, formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase: the cause of cellular ATP depletion in nephrotic cystinosis?" in: Journal of biosciences, Vol. 35, Issue 1, pp. 21-5, (2010) (PubMed).

Aldahmesh, Humeidan, Almojalli, Khan, Rajab, AL-Abbad, Meyer, Alkuraya: "Characterization of CTNS mutations in Arab patients with cystinosis." in: Ophthalmic genetics, Vol. 30, Issue 4, pp. 185-9, (2009) (PubMed).

Macías-Vidal, Rodés, Hernández-Pérez, Vilaseca, Coll: "Analysis of the CTNS gene in 32 cystinosis patients from Spain." in: Clinical genetics, Vol. 76, Issue 5, pp. 486-9, (2009) (PubMed).

Synonyms and alternative names related to CTNS

cystinosin, lysosomal cystine transporter (CTNS), cystinosin, lysosomal cystine transporter (Ctns), cystinosis, nephropathic (Ctns), cystinosin, lysosomal cystine transporter (ctns), cystinosis, nephropathic (CTNS), cystinosin, lysosomal cystine transporter L homeolog (ctns.L), AI195360, AW049661, CTNS, CTNS-LSB, PQLC4, zgc:110194

Protein level used designations for CTNS

  • cystinosin
  • cystinosis, nephropathic
  • cystinosin-like
  • cystinosin, lysosomal cystine transporter
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