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CTLA4 Proteins

(Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008].

76 results

CTLA4 Origin: Guinea Pig Host: Yeast (Pichia pastoris) Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN6573161
$397.27
Plus shipping costs $50.00, if applicable $20.00 dry ice
50 μg (More quantities available)
Shipping to: United States
Delivery in 11 to 22 Business Days
 
CTLA4 Origin: Mouse Host: Mammalian Cells Recombinant >90 % as determined by SDS-PAGE. WB, SDS, ELISA, Imm, AcA Active
Catalog No. ABIN7678665
$600.74
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 12 to 15 Business Days
 
CTLA4 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 95 % SDS, AcA Active
Catalog No. ABIN7677079
$503.85
Plus shipping costs $50.00, if applicable $20.00 dry ice
100 μg (More quantities available)
Shipping to: United States
Delivery in 13 to 18 Business Days
 
CTLA4 Origin: Mouse Host: Baculovirus infected Insect Cells Recombinant > 90 % by SDS - PAGE SDS, AcA Active
Catalog No. ABIN7677665
$561.54
Plus shipping costs $50.00, if applicable $20.00 dry ice
100 μg (More quantities available)
Shipping to: United States
Delivery in 13 to 18 Business Days
 
CTLA4 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 90 % SDS, AcA Active
Catalog No. ABIN7677098
$596.15
Plus shipping costs $50.00, if applicable $20.00 dry ice
100 μg (More quantities available)
Shipping to: United States
Delivery in 13 to 18 Business Days
 
CTLA4 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7505718
$762.72
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 11 to 15 Business Days
 
CTLA4 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % WB, SDS, Imm, PC
Catalog No. ABIN7393514
$747.79
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 13 to 17 Business Days
 
CTLA4 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % WB, SDS, Imm, PC
Catalog No. ABIN7422337
$753.80
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 13 to 17 Business Days
 
CTLA4 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % WB, SDS, Imm, PC
Catalog No. ABIN7424968
$763.82
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 13 to 17 Business Days
 
CTLA4 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % WB, SDS, Imm, PC
Catalog No. ABIN7406020
$785.85
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 13 to 17 Business Days
 
CTLA4 Origin: Rat Host: Escherichia coli (E. coli) Recombinant > 95 % WB, SDS, Imm, PC
Catalog No. ABIN7405660
$795.87
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 13 to 17 Business Days
 
CTLA4 Origin: Human Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE. Active
Catalog No. ABIN7319733
$1,240.80
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 11 to 15 Business Days
 
CTLA4 Origin: Mouse Host: Mammalian Cells Recombinant > 90 % Inactive
Catalog No. ABIN7668632
$2,133.60
Plus shipping costs $50.00
500 μg
Shipping to: United States
Delivery in 11 to 15 Business Days
 
CTLA4 Origin: Mouse Host: Mammalian Cells Recombinant > 90 % Inactive
Catalog No. ABIN7668631
$2,133.60
Plus shipping costs $50.00
500 μg
Shipping to: United States
Delivery in 11 to 15 Business Days
 
CTLA4 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2713435
$1,152.00
Plus shipping costs $50.00, if applicable $20.00 dry ice
20 μg
Shipping to: United States
Delivery in 11 to 12 Business Days
 
CTLA4 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2713434
$1,152.00
Plus shipping costs $50.00, if applicable $20.00 dry ice
20 μg
Shipping to: United States
Delivery in 11 to 12 Business Days
 
CTLA4 Origin: Human Host: CHO Cells Recombinant > 95 % , as determined by Coomassie stained SDS-PAGE AbP, STD, Func, PI Active
Catalog No. ABIN2713438
$294.00
Plus shipping costs $50.00, if applicable $20.00 dry ice
10 μg
Shipping to: United States
Delivery in 4 to 9 Business Days
 
CTLA4 Origin: Human, Mouse, Rat Host: Escherichia coli (E. coli) Recombinant WB, PC
Catalog No. ABIN2747619
$338.46
Plus shipping costs $50.00
5 applications
Shipping to: United States
Delivery in 1 to 3 Business Days
 
CTLA4 Origin: Mouse Host: Bacteria Recombinant
Catalog No. ABIN7819790
$520.52
Plus shipping costs $50.00, if applicable $20.00 dry ice
100 μg
Shipping to: United States
Delivery in 7 to 10 Business Days
 
CTLA4 Origin: Rat Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
Catalog No. ABIN7271621
$426.15
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 5 to 6 Business Days
 
  • Type Protein
    • Protein
  • Application
    • Western Blotting (WB)
    • ELISA
    • SDS-PAGE (SDS)
    • Immunogen (Imm)
    • Positive Control (PC)
    • Activity Assay (AcA)
    • Antibody Production (AbP)
    • Mass Spectrometry (MS)
    • Standard (STD)
    • Affinity Measurement (AM)
    • Functional Studies (Func)
    • Immunoassay (IA)
    • Protein Interaction (PI)
    • Screening Assay (ScA)
    • Antibody Drug Assay (ADA)
    • Affinity Purification (AP)
    • Antibody Array (AA)
    • Flow Cytometry (FACS)
  • Reactivity
    • Human
    • Mouse
    • Cynomolgus
    • Rat
    • Rhesus Monkey
    • Guinea Pig
    • Rabbit
    • Treeshrew (Tupaia)
    • Dog
    • Pig
  • Cited in publications
  • Images available
  • Carrier free only
  • Host
    • HEK-293 Cells
    • Human Cells
    • Escherichia coli (E. coli)
    • Mammalian Cells
    • Baculovirus infected Insect Cells
    • Yeast
    • CHO Cells
    • Eukaryota
    • NS1 Cells
    • Yeast (Pichia pastoris)
    • Bacteria
    • HEK-293T Cells
    • Wheat germ
  • Binding Specificity
    • AA 36-161
    • AA 37-162
    • AA 38-161
    • AA 37-160
    • AA 37-161
    • partial
    • AA 36-162
    • Transcript Variant 1
    • AA 1-160
    • AA 1-162
    • AA 35-153
    • AA 36-135
    • AA 36-223
    • AA 38-160
    • AA 41-192
    • AA 45-185
    • AA 52-211
  • Conjugate
    • His tag
    • Fc Tag
    • DYKDDDDK Tag
    • Un-conjugated
    • Fc Tag,AVI tag
    • GST tag
    • His tag,AVI tag,Biotin
    • Strep Tag
    • hIgG-His-tag
    • Biotin,His-Avi Tag
    • DYKDDDDK-His Tag
    • Fc Tag,AVI tag,Biotin
    • Fc Tag,His tag
    • His tag,ECD
    • His tag,GST tag
    • His tag,mFc Tag
    • His-DYKDDDDK-Strep II Tag
    • His-Fc tag
    • mFc Tag
  • Protein Type
    • Recombinant
  • Format
    • Lyophilized
    • Liquid
    • Frozen
  • Biological Activity
    • Biologically Active
    • Biologically Inactive
  • Supplier
    • antibodies-online
    • ACROBiosystems
    • ProSci
    • Cohesion Biosciences
    • OriGene
    • CUSABIO
    • ProteoGenix
    • FabGennix

Latest Publications for our CTLA4 Proteins

Bai, Gao, Hu, Liu, Li, Dong, Huang, Zhu, Zhou, Li, Shao: "Self-Assembled Multivalent Aptamer Nanoparticles with Potential CAR-like Characteristics Could Activate T Cells and Inhibit Melanoma Growth." in: Molecular therapy oncolytics, Vol. 17, pp. 9-20, (2020) (PubMed).

Simons, Lim, Carter, Wagner, Wayham, Adler, Johnson: "Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCR." in: mAbs, Vol. 12, Issue 1, pp. 1803646, (2020) (PubMed).

Okada, Kajiya, Omata, Matsumoto, Sato, Kobayashi, Nakamura, Kaneko, Nakamura, Koyama, Sudo, Shin, Okamoto, Watanabe, Tachibana, Hirose, Saito, Takai, Matsumoto, Nakamura, Okabe, Miyamoto, Tanaka: "CTLA4-Ig Directly Inhibits Osteoclastogenesis by Interfering With Intracellular Calcium Oscillations in Bone Marrow Macrophages." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, (2019) (PubMed).

Ganesan, Moon, Barakat: "Revealing the atomistic details behind the binding of B7-1 to CD28 and CTLA-4: A comprehensive protein-protein modelling study." in: Biochimica et biophysica acta. General subjects, Vol. 1862, Issue 12, pp. 2764-2778, (2019) (PubMed).

Galstyan, Markman, Shatalova, Chiechi, Korman, Patil, Klymyshyn, Tourtellotte, Israel, Braubach, Ljubimov, Mashouf, Ramesh, Grodzinski, Penichet, Black, Holler, Sun, Ding, Ljubimov, Ljubimova: "Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy." in: Nature communications, Vol. 10, Issue 1, pp. 3850, (2019) (PubMed).

Gonzalez-Nieto, Castro, Bischof, Shin, Ricciardi, Bailey, Dang, Pedreño-Lopez, Magnani, Ejima, Allison, Gil, Evans, Rakasz, Lifson, Desrosiers, Martins: "Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques." in: PLoS pathogens, Vol. 15, Issue 9, pp. e1008015, (2019) (PubMed).

Ganesan, Ahmed, Okoye, Arutyunova, Babu, Turnbull, Kundu, Shields, Agopsowicz, Xu, Tabana, Srivastava, Zhang, Moon, Belovodskiy, Hena, Kandadai, Hosseini, Hitt, Walker, Smylie, West, Siraki, Lemieux et al.: "Comprehensive in vitro characterization of PD-L1 small molecule inhibitors. ..." in: Scientific reports, Vol. 9, Issue 1, pp. 12392, (2019) (PubMed).

Zhao, Lee, Lin, Gassen, Xu, Huang, Xiao, Bonorino, Lu, Bui, Hui: "PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways." in: Immunity, Vol. 51, Issue 6, pp. 1059-1073.e9, (2019) (PubMed).

Waight, Chand, Dietrich, Gombos, Horn, Gonzalez, Manrique, Swiech, Morin, Brittsan, Tanne, Akpeng, Croker, Buell, Stein, Savitsky, Wilson: "Selective FcγR Co-engagement on APCs Modulates the Activity of Therapeutic Antibodies Targeting T Cell Antigens." in: Cancer cell, Vol. 33, Issue 6, pp. 1033-1047.e5, (2019) (PubMed).

Ljungars, Svensson, Carlsson, Birgersson, Tornberg, Frendéus, Ohlin, Mattsson: "Deep Mining of Complex Antibody Phage Pools Generated by Cell Panning Enables Discovery of Rare Antibodies Binding New Targets and Epitopes." in: Frontiers in pharmacology, Vol. 10, pp. 847, (2019) (PubMed).

Aliases for CTLA4 Proteins

cytotoxic T-lymphocyte associated protein 4 (CTLA4) Proteins
cytotoxic T-lymphocyte-associated protein 4 (Ctla4) Proteins
CD Proteins
CD152 Proteins
Cd152 Proteins
CELIAC3 Proteins
CTLA-4 Proteins
Ctla-4 Proteins
CTLA4 Proteins
GRD4 Proteins
GSE Proteins
IDDM12 Proteins
Ly-56 Proteins
sCTLA4 Proteins
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