CTLA4 Proteins
(Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008].
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85 results
CTLA4
Origin: Human
Host: Human Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
CTLA4
Origin: Human
Host: Human Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
CTLA4
Origin: Human
Host: CHO Cells
Recombinant
>98 % (SDS-PAGE)
Active
CTLA4
Origin: Human
Host: HEK-293 Cells
Recombinant
>95 % (SDS-PAGE)
Active
CTLA4
Origin: Human
Host: HEK-293 Cells
Recombinant
>95 % (SDS-PAGE)
Active
CTLA4
Origin: Guinea Pig
Host: Yeast (Pichia pastoris)
Recombinant
> 95 % as determined by reducing SDS-PAGE.
CTLA4
Origin: Human
Host: CHO Cells
Recombinant
>98 % (SDS-PAGE)
Active
CTLA4
Origin: Mouse
Host: NS1 Cells
Recombinant
>98 % (SDS-PAGE)
Active
CTLA4
Origin: Human
Host: CHO Cells
Recombinant
>98 % (SDS-PAGE)
Active
CTLA4
Origin: Mouse
Host: NS1 Cells
Recombinant
>98 % (SDS-PAGE)
Active
CTLA4
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
WB, SDS, ELISA
CTLA4
Origin: Mouse
Host: Mammalian Cells
Recombinant
>90 % as determined by SDS-PAGE.
WB, SDS, ELISA, Imm, AcA
Active
CTLA4
Origin: Human
Host: HEK-293 Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
CTLA4
Origin: Human
Host: Baculovirus infected Insect Cells
Recombinant
> 90% by SDS-PAGE
SDS, AcA
Active
CTLA4
Origin: Human
Host: Baculovirus infected Insect Cells
Recombinant
> 95% by SDS-PAGE
SDS, AcA
Active
CTLA4
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
> 95 %
WB, SDS, Imm, PC
CTLA4
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
> 90 %
WB, SDS, Imm, PC
CTLA4
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
> 90 %
WB, SDS, Imm, PC
Latest Publications for our CTLA4 Proteins
: "Self-Assembled Multivalent Aptamer Nanoparticles with Potential CAR-like Characteristics Could Activate T Cells and Inhibit Melanoma Growth." in: Molecular therapy oncolytics, Vol. 17, pp. 9-20, (2020) (PubMed).: "Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCR." in: mAbs, Vol. 12, Issue 1, pp. 1803646, (2020) (PubMed).
: "CTLA4-Ig Directly Inhibits Osteoclastogenesis by Interfering With Intracellular Calcium Oscillations in Bone Marrow Macrophages." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, (2019) (PubMed).
: "Revealing the atomistic details behind the binding of B7-1 to CD28 and CTLA-4: A comprehensive protein-protein modelling study." in: Biochimica et biophysica acta. General subjects, Vol. 1862, Issue 12, pp. 2764-2778, (2019) (PubMed).
: "Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy." in: Nature communications, Vol. 10, Issue 1, pp. 3850, (2019) (PubMed).
: "Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques." in: PLoS pathogens, Vol. 15, Issue 9, pp. e1008015, (2019) (PubMed).
: "Comprehensive in vitro characterization of PD-L1 small molecule inhibitors. ..." in: Scientific reports, Vol. 9, Issue 1, pp. 12392, (2019) (PubMed).
: "PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways." in: Immunity, Vol. 51, Issue 6, pp. 1059-1073.e9, (2019) (PubMed).
: "Selective FcγR Co-engagement on APCs Modulates the Activity of Therapeutic Antibodies Targeting T Cell Antigens." in: Cancer cell, Vol. 33, Issue 6, pp. 1033-1047.e5, (2019) (PubMed).
: "Deep Mining of Complex Antibody Phage Pools Generated by Cell Panning Enables Discovery of Rare Antibodies Binding New Targets and Epitopes." in: Frontiers in pharmacology, Vol. 10, pp. 847, (2019) (PubMed).
Aliases for CTLA4 Proteins
cytotoxic T-lymphocyte associated protein 4 (CTLA4) Proteinscytotoxic T-lymphocyte-associated protein 4 (Ctla4) Proteins
CD Proteins
CD152 Proteins
Cd152 Proteins
CELIAC3 Proteins
CTLA-4 Proteins
Ctla-4 Proteins
CTLA4 Proteins
GRD4 Proteins
GSE Proteins
IDDM12 Proteins
Ly-56 Proteins
sCTLA4 Proteins
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- CTD Nuclear Envelope Phosphatase 1 Regulatory Subunit 1 Proteins
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- CTNNA3 Proteins
- CTNNAL1 Proteins
- CTNNB1 Proteins
- CTNNBIP1 Proteins
- CTNNBL1 Proteins
- CTNND1 Proteins
- CTNND2 Proteins
- CTNS Proteins
- CTP Synthase Proteins
- CTPS2 Proteins
- CTRP5 Proteins
- CTRP6 Proteins
- CTRP7 Proteins
- CTSA Proteins
- CTSC Proteins
- CTSO Proteins
- CTU2 Proteins
- CUBN Proteins
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