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Low expression level of FOLR1 is associated with neuroendocrine lung tumors.
FolR1 is a predictive candidate and a therapeutic target for medulloblastoma.
Folr1 is a favorable target for fluorescence-guided surgery as tumor specific agent EC17 produced a clear fluorescent signal in ovarian and breast cancer tissue.
The Folate receptor alpha is associated with the progression of cervical cancer and regulates cervical cancer cells growth through phosphorylating ERK1/2, c-Fos, and c-Jun (show JUN Proteins), which are key factors of the ERK (show EPHB2 Proteins) signaling pathway.
Folate receptor alpha protein was expressed in the majority of lung adenocarcinomas and a minority of lung squamous cell carcinomas. Folate receptor alpha protein expression correlated with histologic grade for lung adenocarcinomas, and the greatest difference was observed between grade 1 and grade 3.
The present study shows the efficacy of silencing HuR (show ELAVL1 Proteins) in lung cancer cells using folate-conjugated nanoparticle system that is directed towards folate receptor-alpha overexpressing cancer cells.
Suppression of FOLR1 by RNA interference altered gene expression profile of taxol-resistant nasopharyngeal carcinoma cells. Apoptosis-related genes, gene alterations in viral carcinogenesis/MAPK (show MAPK1 Proteins) pathways may be important for taxol resistance reversal.
we confirmed the similarities between epithelial ovarian cancer and fallopian tube, normal and adenocarcinoma using FOLR1, FOLR2 (show FOLR2 Proteins), CD68 (show CD68 Proteins) and CD11b (show ITGAM Proteins) markers
Suggest RNA CAR T cell therapy for the treatment of common epithelial cancers expressing folate receptor-alpha.
Folate receptor (show FOLR3 Proteins) expression on murine and human adipose tissue macrophages
These findings support a model in which the folate receptor (show FOLR3 Proteins) interacts with cell adhesion molecules, thus regulating the apical cell membrane remodeling and cytoskeletal dynamics necessary for neural plate folding.
This study presented the disintegration of folate from bovine FOLR1 during high temperature processing.
summarizes recent biochemical, analytical, food science, and nutritional advances regarding folate-binding protein (show GNMT Proteins) in milk [REVIEW]
ligand binding characteristics and aggregation behavior depends on the presence of amphiphatic substances [folate binding protein (show GNMT Proteins)]
FOLR1 is a key regulatory point of folate metabolism for milk protein (show CSN2 Proteins) synthesis within mammary epithelial cells.
Results show that the gene zgc:165502 is an orthologue of human Folate Receptor 1 located on chromosome 15 and is expressed globally during cleavage and gastrulation.
Folate receptor alpha upregulates Oct4 (show POU5F1 Proteins), Sox2 (show SOX2 Proteins) and Klf4 (show KLF4 Proteins) and downregulates miR (show MLXIP Proteins)-138 and miR (show MLXIP Proteins)-let-7 in cranial neural crest cells.
Quantitative RT-PCR showed that Slc19a1 (show SLC19A1 Proteins) mRNA was expressed in mouse cumulus-oocyte complexes (COCs) and oocytes, whereas Folr1 showed expression only in preimplantation embryos, increasing from the 2-cell stage onward.
under conditions of reduced folate (Folr-/-) signalling, pathways crucial for proper development of the neural tube are significantly altered.
Nesting of T helper cell epitopes results in recruitment of latent pools of naive high-affinity/avidity folate receptor (show FOLR3 Proteins) (FR)alpha-specific T cells, which have the ability to home to tumors expressing FRalpha and to reduce tumor burden.
Fbp1 (show FBP2 Proteins) has a role in anterior neural tube closure
Abnormal heart looping was observed during early development of Folr1(-/-) embryos partially rescued by maternal folinic acid supplementation.
folate receptor (show FOLR3 Proteins) type beta is induced in a bone marrow engraftment model of acute myelogenous leukemia
Folr1 gene ablation and abnormal folate homeostasis altered gene expression in developing heart and conotruncal tissues
These findings findings suggest that FRalpha plays a role in pituitary tumor formation, and this effect may in part be due to its regulation of the NOTCH3 (show NOTCH3 Proteins) pathway.
The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.
, KB cells FBP
, adult folate-binding protein
, folate binding protein
, folate receptor alpha
, folate receptor, adult
, ovarian tumor-associated antigen MOv18
, erythroid-specific folate receptor
, membrane-bound folate binding protein
, folate receptor 1 (adult)
, Folate receptor alpha
, milk folate-binding protein
, folate binding protein 1
, folate-binding protein 1