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there is a disulfide bond between Cys245 and Cys279 in SNAT2 which has no effect on cell surface trafficking, as well as transporter function
In the absence of SLC1A5 there is a crucial role of SNAT1 in supplying glutamine for glutaminolysis with SNAT2 acting as a "backup" for glutamine transport.
Propose regulation of placental SNAT2/LAT1 (show LAT Proteins) ubiquitination by mTORC1 and Nedd4-2 (show NEDD4L Proteins).
Decreased placental mTOR (show FRAP1 Proteins) activity causes down-regulation of placental system A activity by shifting SNAT-2 trafficking towards proteasomal degradation, thereby contributing to decreased fetal amino acid availability and restricted fetal growth in IUGR.
GADD34 (show PPP1R15A Proteins) promotes cell survival and adaptation to increased extracellular osmolarity by increasing the uptake of small neutral amino acids via the amino acid transporter (show SLC43A2 Proteins) SNAT2.
Increased availability of unsaturated fatty acids can compromise the stress-induced induction/adaptation in SNAT2 expression.
SLC38A1 and SLC38A2 transcript levels are altered in placental malaria with intervillositis.
SNAT2 mRNA levels were significantly decreased in intrauterine growth-restricted placentas with reduced umbilical blood flows.
Placental mRNA expression of system A transporter isoforms SLC38A1 and -2 was lower in teenagers than in adults which may underlie their susceptibility to delivering small-for-gestational-age infants.
findings show methylation status of rRNA differentially influenced the mechanism of 80S complex formation on IRES elements from SNAT2)versus the hepatitis C virus mRNA
Changes in transporter expression likely reflect different amino acid requirements during development. Findings include the differential expression of SNAT1 in the inner and outer cells of the compacted morula and nuclear localisation of SNAT2 in the trophectoderm and placental lineages.
GADD34 (show PPP1R15A Proteins) promotes cell survival and adaptation to increased extracellular osmolarity by increasing the uptake of small neutral amino acids via the amino acid transporter ATA2.
These data reveal an unexpected role for amino acid uptake and the amino acid transporter SNAT2 in regulation of pluripotent cells in culture.
The inward current of Na(+) associated with the function of SNAT2 leads to membrane depolarization and activation of voltage-sensitive Ca(2 (show CA2 Proteins)+) channels that mediate Ca(2 (show CA2 Proteins)+) influx, thereby leading to an increase in the [Ca(2 (show CA2 Proteins)+)](i) in enteroendocrine cells.
Insulin (show INS Proteins) promotes the cell surface recruitment of the SAT2/ATA2 system A amino acid transporter from an endosomal compartment in skeletal muscle cells. (ATA2 or SAT2 (show SAT2 Proteins))
crosstalk between an imprinted growth demand gene (Igf2) and placental supply transporter genes (Slc38a4 (show SLC38A4 Proteins), Slc38a2, and Slc2a3 (show SLC2A3 Proteins)) may be a component of the genetic control of nutrient supply and demand during mammalian development
ATA2 on the plasma membrane is subject to polyubiquitination by Nedd4-2 (show NEDD4L Proteins) with consequent endocytotic sequestration and proteasomal degradation
the insulin (show INS Proteins)-stimulated translocation pathways for ATA2 and GLUT4 (show SLC2A4 Proteins) in adipocytes are distinct, involving different storage sites
SNAT2 not only regulates mTOR (show FRAP1 Proteins) but also regulates proteolysis through PI3K and provides a link among acidosis, insulin (show INS Proteins) resistance, and protein wasting in skeletal muscle cells.
Despite increased ATF4 (show ATF4 Proteins) binding at the C/EBP (show CEBPA Proteins)-ATF composite site following activation of the unfolded protein response, system A transporter 2 (SNAT2) transcription activity is repressed
Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1 (By similarity).
solute carrier family 38, member 2
, Amino acid transporter A2
, sodium-coupled neutral amino acid transporter 2
, sodium-coupled neutral amino acid transporter 2-like
, amino acid transporter A2
, system A amino acid transporter 2
, system A transporter 1
, system N amino acid transporter 2
, amino acid transporter 2
, protein 40-9-1
, solute carrier family 38 member 2
, amino acid system A transporter
, amino acid transporter cationic 2
, amino acid transporter system A2
, amino acid transporter, cationic 2 (low affinity)
, Sodium-coupled neutral amino acid transporter 2
, Solute carrier family 38 member 2
, System A amino acid transporter 2
, System A transporter 1
, System N amino acid transporter 2