|Antigen||Family with Sequence Similarity 175, Member A (FAM175A) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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|Specificity||This antibody reacts to CCDC98.|
|Purification||Affinity chromatography purified via peptide column|
|Immunogen||CCDC98 antibody was raised against a 15 amino acid peptide from near the amino terminus of human CCDC98.|
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|Alternative Name||CCDC98 (FAM175A Antibody Abstract)|
|Background||CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.Synonyms: ABRA1, Abraxas, BRCA1-A complex subunit Abraxas, Coiled-coil domain-containing protein 98, Protein FAM175A|
|Pathways||DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus|
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ELISA. Western Blot: CCDC98 antibody can be used for detection of CCDC98 at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
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|Buffer||PBS containing 0.02 % sodium azide.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store the antibody undiluted at 2-8 °C.|