anti-Mouse (Murine) Family with Sequence Similarity 175, Member A antibody for Enzyme Immunoassay

Recommended Family with Sequence Similarity 175, Member A Antibody (supplied by: Log in to see )

Antigen
Family with Sequence Similarity 175, Member A (FAM175A) Antibodies
  • CCDC98
  • abra1
  • ccdc98
  • fam175a
  • ABRA1
  • 3830405G04Rik
  • 5630400M01Rik
  • AI506069
  • AL024423
  • AV118690
  • Ccdc98
  • RGD1305287
  • zgc:103522
  • abraxas 1, BRCA1 A complex subunit
  • Coiled-coil domain-containing protein 98
  • BRCA1 A complex subunit
  • family with sequence similarity 175 member A
  • abraxas 2a, BRISC complex subunit
  • abraxas 1, BRCA1 A complex subunit S homeolog
  • ABRAXAS1
  • abraxas1
  • Abraxas1
  • FAM175A
  • abraxas2a
  • abraxas1.S
Epitope
N-Term
11
7
5
3
3
2
Reactivity
Human, Mouse (Murine)
55
25
20
4
2
2
1
1
1
1
Host
Rabbit
46
10
Clonality
Polyclonal
Conjugate
Un-conjugated
3
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
41
22
18
16
15
13
9
4
1
Options
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Catalog No. ABIN5554676
$ 522.50
Plus shipping costs $45.00

General

Antigen Family with Sequence Similarity 175, Member A (FAM175A) Antibodies
Epitope N-Term
(11), (7), (5), (3), (3), (2)
Reactivity Human, Mouse (Murine)
(55), (25), (20), (4), (2), (2), (1), (1), (1), (1)
Host Rabbit
(46), (10)
Clonality
Polyclonal
Conjugate Un-conjugated
(3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(41), (22), (18), (16), (15), (13), (9), (4), (1)
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Product details

Target Details Application Details Handling Images
Specificity This antibody reacts to CCDC98.
Purification Affinity chromatography purified via peptide column
Immunogen CCDC98 antibody was raised against a 15 amino acid peptide from near the amino terminus of human CCDC98.
Isotype IgG

Target Details

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Antigen
Alternative Name CCDC98 (FAM175A Antibody Abstract)
Background CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.Synonyms: ABRA1, Abraxas, BRCA1-A complex subunit Abraxas, Coiled-coil domain-containing protein 98, Protein FAM175A
Gene ID 84142
NCBI Accession NP_620775
UniProt Q6UWZ7
Pathways DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus

Application Details

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Application Notes ELISA. Western Blot: CCDC98 antibody can be used for detection of CCDC98 at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

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Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.