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Results show that both Cdc6 and Cdt1 (show CDT1 Proteins), when expressed in a high level, alone or in combination, were significantly associated with poorer survival in the breast cancer patient cohort. In line with this finding, the expression of Cdc6 and Cdt1 (show CDT1 Proteins) was upregulated in breast cancer cells compared to normal breast epithelial cells. Expression of Cdc6 and Cdt1 (show CDT1 Proteins) was significantly higher in ER negative breast cancer.
Results suggested that Cdc6 controls centrosome duplication in a manner independent of its recruitment of PCM (show PCMT1 Proteins) proteins to the centrosome.
WHSC1L1 (show WHSC1L1 Proteins) and H3K36me2 are enriched in the gene bodies of the cell cycle-related genes CDC6 and CDK2 (show CDK2 Proteins), implying that WHSC1L1 (show WHSC1L1 Proteins) directly regulates the transcription of these gene
Cdc6 expression is up-regulated in bladder cancer tissues and is positively correlated to high tumor grade.
PPP2R3B (show PPP2R3B Proteins) codes for the PR70 protein, a regulatory substrate-recognizing subunit of protein phosphatase 2A. PR70 decreased melanoma growth by negatively interfering with DNA replication and cell cycle progression through its role in stabilizing CDC6-chromatin licensing and CDT1 (show CDT1 Proteins) interaction
AZD7762 demonstrates synergy with regard to inhibition of AR-CDC6-ATR (show ANTXR1 Proteins)-Chk1 (show CHEK1 Proteins) signaling.
The opposing effects of ORC1 (show ORC1L Proteins) (represor) and CDC6 (gene activator) in controlling the level of Cyclin E (show CCNE1 Proteins) ensures genome stability and a mechanism for linking directly DNA replication and cell division commitment.
Data suggest that regulation of microtubule nucleation and recruitment of pericentriolar proteins to centrosome requires Cdc6 ATPase activity, as well as centrosomal localization of Cdc6.
6 overexpression may contribute to the high proliferation and low apoptosis in chronic myeloid leukemia (show BCL11A Proteins) cells and can be regulated by BCR/ABL (show ABL1 Proteins) signal transduction through downstream phosphoinositide 3-kinase/Akt (show AKT1 Proteins) and Janus kinase/signal transducer and activator of transcription (show STAT1 Proteins) pathways, suggesting cell division cycle protein 6 as a potential therapeutic target in chronic myeloid leukemia (show BCL11A Proteins).
the level of Cdc6 phosphorylation at serine 54 (S54P) was increased in E7-expressing cells. S54P was associated with an increase in the total amount of Cdc6 and chromatin-bound Cdc6. DNA damage-enhanced upregulation and chromatin binding of Cdc6 appeared to be due to downregulation of cyclin-dependent kinase 1 (Cdk1 (show CDK1 Proteins)) as Cdk1 (show CDK1 Proteins) knockdown increased Cdc6 levels
Dele (show KIAA0141 Proteins) and Cdc6 G-quadruplex formation is significant in the transcriptional regulation. Dele (show KIAA0141 Proteins) and Cdc6 G-quadruplex DNA alone possess enhancer and promotor function.
CDK1 (show CDK1 Proteins) activation proceeds with concomitant inhibition by CDC6, which tunes the timing of the M-phase entry during the embryonic cell cycle
Cdc6 continued to block apoptosome assembly induced by a non-cytochrome c (show CYCS Proteins) or some other mechanism, suppressing seemingly unintended apoptosis when promoting cell proliferation
show that MyoD can occupy an E-box within the promoter of Cdc6 and that this association, along with E2F3a, is required for its activity.
CDC6 is essential for spindle formation in mouse oocytes
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.
CDC6 cell division cycle 6 homolog
, CDC6-related protein
, cdc18-related protein
, cell division control protein 6 homolog
, cell division cycle 6 homolog