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ectopic expression of Gene 33 triggers DNA damage response in an ATM serine/threonine kinase (ATM)-dependent fashion and through pathways dependent or not dependent on ABL proto-oncogene 1 non-receptor tyrosine kinase (c-Abl).
our data suggest that dormant cancer cells with a high MIG6 expression level might be one of the causes of EGFR (show EGFR Antibodies)-TKI resistance in EGFR (show EGFR Antibodies) mutant lung cancer cells.
Down-regulation of Mig-6 induces Cyclin D1 (show CCND1 Antibodies) expression and activates the MAPK-ERK (show MAPK1 Antibodies) signaling pathway. Our study shows that the expression of Mig-6 protein is low in hepatocellular carcinoma, which predicts a poor prognosis.
PIPKIgammai5, NEDD4-1 (show NEDD4 Antibodies), and Mig6 form a novel molecular nexus that controls EGFR (show EGFR Antibodies) activation and downstream signaling.
Low MIG6 expression is associated with lung cancer.
MIG6 down regulation may promote the migration and invasiveness of MEK (show MAP2K1 Antibodies) inhibited mutant NRAS (show NRAS Antibodies) melanoma.
MIG6 is a potent tumor suppressor for mutant EGFR (show EGFR Antibodies)-driven lung tumor initiation and progression in mice and provides a possible mechanism by which mutant EGFR (show EGFR Antibodies) can partially circumvent this tumor suppressor in human lung adenocarcinoma.
Crystal structures of human EGFR (show EGFR Antibodies)-Mig6 complexes show how Mig6 rearranges after phosphorylation by EGFR (show EGFR Antibodies) to effectively irreversibly inhibit the same receptor that catalyzed its phosphorylation.
MIG-6 efficiently reduces cellular transformation driven by oncogenic BRAF (show BRAF Antibodies) by orchestrating a negative feedback circuit directed towards the EGFR (show EGFR Antibodies).
study provides a new molecular mechanism to regulate EGFR (show EGFR Antibodies) signaling through modulation of MIG6 by DNAJB1 (show DNAJB1 Antibodies) as a negative regulator.
Studies indicate that progesterone receptor (show PGR Antibodies) transgenic (Pgrcre/+) mitogen inducible gene 6 (Mig (show CXCL9 Antibodies)-6over) phosphatase and tensin homolog (show PTEN Antibodies) protein (Ptenf/f) knockout mice exhibited an increase of phospho-ERK1/2 (show MAPK1/3 Antibodies) and its target genes.
mouse Mig-6 ablation in the liver results in multiple metabolic phenotypes such as fatty liver, fasting hyperglycemia, and hypercholesterolemia but in lower bodyweight and improved insulin (show INS Antibodies) sensitivity.
Liver-specific ablation of Mig-6 caused hyperglycemia by hepatic insulin (show INS Antibodies) resistance.
This microarray analysis also revealed that 324 genes are regulated by P4 as well as Mig-6. Cited2 (show CITED2 Antibodies), the developmentally important transcription factor, was identified as being regulated by the P4-Mig-6 axis
Mig-6 plays a critical role in the development of atherosclerosis.
our findings suggest that Mig-6 regulates ERK1/2 (show MAPK1/3 Antibodies) phosphorylation and that it is crucial for progression of PTEN (show PTEN Antibodies)-mutant endometrial cancers, providing a mechanistic rationale for the evaluation of ERK1/2 (show MAPK1/3 Antibodies) inhibitors
MIG-6 expression in chondrocytes is important for the maintenance of cartilage and joint homeostasis.
Cartilage-specific deletion of Mig-6 results in osteoarthritis-like disorder with excessive articular chondrocyte proliferation.
This treatment had no effect in PR(cre/+)Mig-6(f/f) mice where Mig-6 was deleted in both the epithelial and stromal compartments of the uterus.
Fibroblast growth factor signaling requires Xmig6 for muscle differentiation in Xenopus embryos. Fibroblast growth factor signaling may involve XGPCR4 (show GPR84 Antibodies) in gastrulation.
ERRFI1 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995
mitogen-inducible gene 6 protein
, receptor-associated late transducer
, 60S ribosomal protein L36a
, 60S ribosomal protein L44
, L44-like ribosomal protein
, cell growth-inhibiting gene 15 protein
, cell migration-inducing gene 6 protein
, dJ164F3.3 (ribosomal protein L44)
, mitogen-inducible gene 6 protein homolog
, gene 33 polypeptide
, ERBB receptor feedback inhibitor 1
, mitogen-inducible gene 6-like protein
, ERBB receptor feedback inhibitor 1-like