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EXOSC5 Products

(Exosome Component 5 (EXOSC5))

Categories

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes (By similarity).

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Featured EXOSC5 Categories

EXOSC5 Antibodies

High quality antibodies with extensive validation data.

EXOSC5 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended EXOSC5 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, WB, IHC
Validations
  • (3)
Cat. No. ABIN7152293
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (3)
Cat. No. ABIN528003
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (3)
Cat. No. ABIN528001
Quantity 50 μg
Datasheet Datasheet

Recommended EXOSC5 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6208683
Quantity 96 tests
Datasheet Datasheet

Recommended EXOSC5 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122863
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1353244
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1353246
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our EXOSC5 products

Rege, Subramanian, Zhu, Hsieh, Weiner, Friedman, Clauder-Münster, Steinmetz, Rando, Boyer, Peterson: "Chromatin Dynamics and the RNA Exosome Function in Concert to Regulate Transcriptional Homeostasis." in: Cell reports, Vol. 13, Issue 8, pp. 1610-22, (2015) (PubMed).

Synonyms and alternative names related to EXOSC5

exosome component 5 (exosc5), exosome component 5 (EXOSC5), exosome component 5 (Exosc5), D7Wsu180e, EXOSC5, hRrp46p, p12B, RRP41B, RRP46, Rrp46p, si:ch211-194n6.2, zgc:153707

Protein level used designations for EXOSC5

  • exosome complex exonuclease RRP46
  • exosome component 5
  • chronic myelogenous leukemia tumor antigen 28
  • exosome complex component RRP46
  • exosome component Rrp46
  • ribosomal RNA-processing protein 46
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