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Mouse UBR3 poly-ubiquitinates Kif7, the mammalian homologue of Cos2. Finally, loss of UBR3 up-regulates Kif7 protein levels and decreases Hh signaling in cultured cells.
Knockout of the Ubr3 gene in mouse embryonic fibroblasts leads to an up-regulation of the cellular levels of APE1 protein and subsequent genomic instability.
the UBR box of UBR3 may recognize small compounds that modulate the targeting, by this E3, of its currently unknown substrates
UBR3/6 regulate cardiomyocyte Nav 1.5 channel protein levels via the ubiquitin-proteasome pathway.
The human E3 ubiquitin ligase UBR3 has a major activity that polyubiquitylates APE1 at multiple lysine residues clustered on the N-terminal tail.
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Does not bind to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
zinc finger protein 650
, ubiquitin protein ligase E3 component n-recognin 3 (putative)
, E3 ubiquitin-protein ligase UBR3
, ubiquitin-protein ligase E3-alpha-3
, ubiquitin-protein ligase E3-alpha-III