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This study is the first to identify the roles of FOXM1 (show FOXM1 Proteins) in drug efflux and paclitaxel resistance by regulating the gene transcription of abcc5, one of the ABC (show ABCB6 Proteins) transporters. Small molecular inhibitors of FOXM1 (show FOXM1 Proteins) or ABCC5 have the potential to overcome paclitaxel chemoresistance in nasopharyngeal carcinoma (NPC (show NPC1 Proteins))patients.
These findings enrich the allelic spectrum of ABCC5 in PACG. We identified no tagging SNP responsible for the association of the whole region.
Survivors of childhood acute lymphoblastic leukemia treated with doxorubicin with the ABCC5 TT-1629 genotype had an average of 8-12% reduction of ventricular ejection and shortening fractions.
our work indicated that decreased SLC34A2 (show SLC34A2 Proteins) expression sensitized BCSCs to doxorubicin via SLC34A2 (show SLC34A2 Proteins)-Bmi1 (show BMI1 Proteins)-ABCC5 signaling and shed new light on understanding the mechanism of chemoresistance in BCSCs. This study not only bridges the missing link between stem cell-related transcription factor (Bmi1 (show BMI1 Proteins)) and ABC transporter (ABCC5) but also contributes to development of potential therapeutics against breast cancer.
Deletions of ABCC5 predict good tumor response to neoadjuvant chemotherapy in breast cancer.
genetic association study in population in Mexico: Data suggest SNPs in ABCC5 (3933+313T>C) are not associated with adverse reactions to methotrexate; they protect against myelosuppression in pediatric patients with ALL (acute lymphoblastic leukemia).
We identified several genes (FasL (show FASL Proteins), MSH2 (show MSH2 Proteins), ABCC5, CASP3 (show CASP3 Proteins), and CYP3A4 (show CYP3A4 Proteins))that showed association with PFS in patients with osteosarcoma. These pharmacogenetic risk factors might be useful to predict treatment outcome
ABCC5 is a general glutamate (show GRIN1 Proteins) conjugate and analog transporter that affects the disposition of endogenous metabolites, toxins, and drugs.
The present study investigated the time course and dose dependency of the induction of three efflux proteins, P-gp (show ABCB4 Proteins), MRP1 (show MDM4 Proteins) and MRP5, in response to gemcitabine exposure in Capan-2 pancreatic cancer cell line at transcriptional and translational levels.
cCMP is a substrate for MRP5
Deficiency of MKP5 (show DUSP10 Proteins) resulted in increased inflammatory activation in macrophages. These findings thus demonstrate that MKP5 (show DUSP10 Proteins) critically controls inflammation in white adipose tissue and the development of metabolic disorders
Reduced cGMP export as a consequence of decreased MRP5 expression can attenuate heart failure in sepsis.
Higher expression of MRP5 in muscle cells from fundus correlates with tonic phenotype of muscle.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected\; however, the complete sequence and translation initiation site is unclear.
ATP-binding cassette sub-family C member 5
, canalicular multispecific organic anion transporter C
, multi-specific organic anion transporter C
, multidrug resistance-associated protein 5
, ATP-binding cassette, sub-family C (CFTR/MRP), member 5a
, ATP-binding cassette, sub-family C (CFTR/MRP), member 5b
, ATP-binding cassette, sub-family C, member 5
, ATP-binding cassette sub-family C (CFTR/MRP) member 5a
, ATP-binding cassette, sub-family C (CFTR/MRP), member 5
, ATP binding cassette subfamily C member 5 L homeolog