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Results show negative regulation of HDAC1 (show HDAC1 Proteins) by a Cul3 (show CUL3 Proteins)-REN E3 ubiquitin ligase (show MUL1 Proteins) complex.
REN is upregulated by neurogenic signals (retinoic acid, EGF (show EGF Proteins), and NGF (show NGFB Proteins)) in embryonal stem (ES) cells and neural progenitor cell lines in association with neurotypic differentiation.
REN protein enhances caspase-3 (show CASP3 Proteins) activation and antagonizes the Shh (show SHH Proteins) pathway suggesting that this gene may represent a restraint of Shh (show SHH Proteins) signaling.
Our study demonstrates and supports that KCTD11, as well as negatively regulated downstream effectors belonging to Hh signaling, plays a role in prostate cancer pathogenesis.
findings identify KCTD11 as a widely down-regulated gene in human cancers, and provide a basis to understand how its expression might be deregulated in tumor cells
Results identify REN(KCTD11) as a suppressor of Hedgehog (show SHH Proteins) signaling and suggest that its inactivation might lead to a deregulation of the tumor-promoting Hedgehog (show SHH Proteins) pathway in medulloblastoma.
Plays a role as a marker and a regulator of neuronal differentiation\; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and nerve growth factor/NGFB. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. May play a role as a tumor repressor and functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1 (By similarity).
potassium channel tetramerisation domain containing 11
, BTB/POZ domain-containing protein KCTD11
, retinoic acid, EGF, and NGF upregulated
, retinoic acid, EGF, NGF induced gene protein
, retinoic acid, EGF, NGF induced gene/potassium channel tetramerization domain containing 11