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Revaprazan HCl

InhA, Func 178307-42-1

Catalog No. ABIN3221718

Quick Overview for Revaprazan HCl (ABIN3221718)

Application

Inhibition Assay (InhA), Functional Studies (Func)

Purpose

Revaprazan Hydrochloride is the hydrochloride salt form of a lipophilic, weak base with potassium-competitive acid blocking (P-CAB) activity. Revaprazan concentrates highly in the gastric parietal cell canaliculus and on entering this acidic environment is instantly protonated and binds competitively and reversibly to the potassium binding site of the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting the pump's activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production.

Characteristics

Target: ATPase inhibitor, Proton Pump inhibitor
Receptor: H+/K+ ATPase

Purification

All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.

Purity

97 % +

Formula

C22H24ClFN4

Solubility

10 mM in DMSO
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Radicicol
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Application Notes

Optimal working dilution should be determined by the investigator.

Restrictions

For Research Use only
Format

Solid

Storage

-20 °C

Storage Comment

For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.

Expiry Date

24 months
Background

Membrane Transporter/Ion Channel

Molecular Weight

398.90 g/mol

CAS-No

178307-42-1

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