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5-Azacytidine

Inh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

/ (5-Azacytidine)

1 image

Catalog No. ABIN7233228

Quick Overview for 5-Azacytidine (ABIN7233228)

Application

Inhibition (Inh)

Chemical Name

4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

Permeability

Cell-permeable

Purpose

DNA hypomethylation agent

Characteristics

Specific inhibitor of DNA methyltransferase. Incorporates into DNA and covalently reacts with and inhibits DNA methyltransferases. Induces demethylation and reactivation of silenced genes. Increases stem cell reprogramming efficiency. Induces cardiac differentiation of human mesenchymal stem cells by activating ERK. Induces apoptosis in multiple myeloma cells via ATR-mediated DNA double strand breaks. Cell permeable.

Purity

>98 %

Formula

C8H12N4O5

Solubility

Soluble in DMSO (up to 25 mg/ml), or in Water (up to 12 mg/ml).
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Restrictions

For Research Use only
Format

Powder

Precaution of Use

GHS – Classification
Acute toxicity, Oral (Category 4), H302
Germ cell mutagenicity (Category 2), H341
Carcinogenicity (Category 1A), H350
Reproductive toxicity (Category 1B), H360
Specific target organ toxicity - repeated exposure (Category 1), H372
Long-term (chronic) aquatic hazard (Category 1), H410

Storage

-20 °C
Background

Ladakamycin, U-18496, NSC-102816, AzaC,Epigenetics,Chromatin,DNA methyltransferase,Stem cells,Cell death,Infectious disease,Apoptosis inducer,DNA damage

Molecular Weight

244.2

CAS-No

320-67-2

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