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Anacardic Acid

Inh 16611-84-0 2-Hydroxy-6-pentadecylbenzoic acid

/ (Anacardic Acid)

1 image

Catalog No. ABIN7233231

Quick Overview for Anacardic Acid (ABIN7233231)

Application

Inhibition (Inh)

Chemical Name

2-Hydroxy-6-pentadecylbenzoic acid

Purpose

HAT Inhibitor

Characteristics

Anacardic acids occur in cashew nut shells and are similar in structure to urushiols, the irritating components of poison ivy. Anacardic acid inhibits histone acetyltransferases (HATs) p300 (IC50 = 8.5 μM) and PCAF (IC50 = 5.0 μM) with no effect on HDACs. It also suppresses expression or activity of proteins involved in invasion and angiogenesis, e.g. MMP-2 (IC50 = 11 μM) and -9. 6-PDSA, a saturated form of anacardic acid, induces macrophage activation via MAPK and NF-κB. When used at 125 μM, it sensitized cancer cells to radiation therapy by reducing histone expression. It also blocks inducible and constitutive activation of NF-κB in leukemia cells.

Purity

>98 %

Formula

C22H36O3

Solubility

Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (15 mg/ml)
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Radicicol
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Restrictions

For Research Use only
Format

Powder

Storage

-20 °C
Background

6-Pentadecylsalicylic acid, 6-PDSA,Cell adhesion,Epigenetics,Posttranslational modification,Cytokine,MAPK,Acetyltransferase,Protease,Immunology,Angiogenesis,Stem cells,Inflammation,Cancer,NFkappaB,Chromatin

Molecular Weight

348.5

CAS-No

16611-84-0

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