EED-226
Quick Overview for EED-226 (ABIN7233249)
Application
Chemical Name
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Purpose
- PRC2 methyltransferase inhibitor
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Characteristics
- Potent and selective allosteric inhibitor (IC50 = 23.4 nM) of the EED subunit of the methyltransferase polycomb repressive complex 2 (PRC2).1,2 Strongly inhibits proliferation of lymphoma cells with EZH2 mutations and causes shrinkage and slower tumor growth in mice in a subcutaneous xenograft model of Karpas422.
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Purity
- >98 %
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Formula
- C17H15N5O3S
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Solubility
- Soluble in DMSO (up to 25 mg/ml)
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Restrictions
- For Research Use only
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Format
- Powder
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Storage
- -20 °C
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Background
- Epigenetics,Proliferation,Protein methyltransferase,Immunology,Cancer,Posttranslational modification,Chromatin
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Molecular Weight
- 369.40
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CAS-No
- 2083627-02-3
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