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EED-226

Inh 2083627-02-3 N-(Furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolol[4,3-c)pyrimidine-5-amine
Catalog No. ABIN7233249

Quick Overview for EED-226 (ABIN7233249)

Application

Inhibition (Inh)

Chemical Name

N-(Furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolol[4,3-c)pyrimidine-5-amine
  • Purpose

    PRC2 methyltransferase inhibitor

    Characteristics

    Potent and selective allosteric inhibitor (IC50 = 23.4 nM) of the EED subunit of the methyltransferase polycomb repressive complex 2 (PRC2).1,2 Strongly inhibits proliferation of lymphoma cells with EZH2 mutations and causes shrinkage and slower tumor growth in mice in a subcutaneous xenograft model of Karpas422.

    Purity

    >98 %

    Formula

    C17H15N5O3S

    Solubility

    Soluble in DMSO (up to 25 mg/ml)
  • Restrictions

    For Research Use only
  • Format

    Powder

    Storage

    -20 °C
  • Background

    Epigenetics,Proliferation,Protein methyltransferase,Immunology,Cancer,Posttranslational modification,Chromatin

    Molecular Weight

    369.40

    CAS-No

    2083627-02-3
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