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Santacruzamate A

Name: Santacruzamate A
Brand: antibodies-online
SKU: ABIN7233286
Price: 88 USD
Availability: InStock

Inh 1477949-42-0 N-[4-Oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid, ethyl ester

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Catalog No. ABIN7233286

Quick Overview for Santacruzamate A (ABIN7233286)

Application

Inhibition (Inh)

Chemical Name

N-[4-Oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid, ethyl ester

Purpose

Ultrapotent HDAC2 inhibitor

Characteristics

A highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium cf. Symploca (IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively). Induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors. Potential therapeutic agent for breast cancer. Attenuates Aβ fragment (Aβ25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance. Ameliorates Alzheimer's disease-like pathology in mouse models.

Purity

>98 %

Formula

C15H22N2O3

Solubility

Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml)
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Radicicol
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Restrictions

For Research Use only
Format

Powder

Precaution of Use

GHS – Classification
Not a hazardous substance

Storage

-20 °C
Background

Epigenetics,Posttranslational modification,Protein deacetylase,Neuroscience,Cell death,Cellular stress,Cancer,Neurodegeneration,Apoptosis inducer,Chromatin

Molecular Weight

278.35

CAS-No

1477949-42-0