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SP2509

Inh 1423715-09-6 (E)-N'-(1-(5-Chloro-2-hydroxyphenyl)ethylidene)-3-(morpholinosulfonyl)benzohydrazide

/ (SP2509)

1 image

Catalog No. ABIN7233293

Quick Overview for SP2509 (ABIN7233293)

Application

Inhibition (Inh)

Chemical Name

(E)-N'-(1-(5-Chloro-2-hydroxyphenyl)ethylidene)-3-(morpholinosulfonyl)benzohydrazide

Purpose

LSD1 Inhibitor

Characteristics

SP2509 is a potent (IC50 = 13 nM), reversible, non-competitive inhibitor of histone demethylase LSD1 (KDM1A), selective over the closely related flavin enzymes MAO A & B, lactate dehydrogenase, several CYPs, or hERG. It inhibits growth and induces differentiation of cancer stem cells, e.g. AML progenitor cells, and promotes autophagy in neuroblastoma cells. It also causes cancer cell death independent if LSD1, possibly through downregulation of Bcl-2 and Mcl-1. Also inhibits HSV-1 infection by blocking viral DNA replication and gene expression.

Purity

>98 %

Formula

C19H20ClN3O5S

Solubility

Soluble in DMSO (up to at least 25 mg/ml)
Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Radicicol
Inh 12772-57-5

Geldanamycin- FITC
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

5-Azacytidine
Inh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

Nicotinamide
Inh 98-92-0 Pyridine-3-carboxylic acid amide

SAHA (Vorinostat)
Inh Cell-permeable 149647-78-9 Suberoylanilide-hydroxamic acid

Phenylbutyrate Na
Inh 1716-12-7 4-Phenylbutyric acid, sodium salt

CI-994
Inh 112522-64-2 4-(Acetylamino)-N-(2-aminophenyl)benzamide

Tranylcypromine hemisulfate (±)
Inh Cell-permeable 13492-01-8 Trans (±)-2-phenylcyclopropanamine, hemisulfate salt

Tenovin-1
Inh 380315-80-0 N-[(4-Acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide

Restrictions

For Research Use only
Format

Powder

Storage

-20 °C
Background

Bcl,Epigenetics,Posttranslational modification,Protein demethylase,Cell death,Cancer Stem Cells,Infectious disease,Cancer,Autophagy,Chromatin

Molecular Weight

437.90

CAS-No

1423715-09-6

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