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UNC-2170 HCl

Inh 1648707-58-7 3-Bromo-N-(3-(tert-butylamino)propyl)benzamide, hydrochloride

/ (UNC-2170 HCl)

1 image

Catalog No. ABIN7233306

Quick Overview for UNC-2170 HCl (ABIN7233306)

Application

Inhibition (Inh)

Chemical Name

3-Bromo-N-(3-(tert-butylamino)propyl)benzamide, hydrochloride

Purpose

Methyl-lysine binding protein inhibitor

Characteristics

UNC-2170, identified by screening, was found to be a μM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170 functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.

Purity

>98 %

Formula

C14H21BrN2O • HCl

Solubility

Soluble in DMSO (up to 40 mg/ml) or in Water (up to 50 mg/ml)
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Restrictions

For Research Use only
Format

Powder

Precaution of Use

GHS – Classification
Not a hazardous substance

Storage

-20 °C
Background

Epigenetics,DNA,Chromatin,DNA repair

Molecular Weight

349.7

CAS-No

1648707-58-7

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