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Data show that interleukin-2 receptor alpha, tumor necrosis factor receptor 1 (show TNFRSF1A Proteins), serum STimulation-2 (IL1RL1 (show IL1RL1 Proteins) gene product), and regenerating islet-derived 3-alpha (show REG3A Proteins) were significantly associated with non-relapse mortality.
Our results show that the frequency of Tregs is altered in a large cohort of long-term T1D patients, a profound decrease in CD25 expression and altered IL-2 (show IL2 Proteins) signaling are typical features of Tregs populations in long-term diabetic patients and their relatives.
High IL2RA expression is associated with CRLF2 (show CRLF2 Proteins)-rearranged acute lymphoblastic leukemia.
Inhibits CD25 translation through regulation of the LKB1 (show STK11 Proteins)-AMPK (show PRKAA1 Proteins)-mTOR (show FRAP1 Proteins) pathway to suppress T cells.
Among patients with a low pretreatment sIL-2R level who exhibited a positive response to R-CHOP, the posttreatment sIL-2R level may help to identify those with a poor prognosis.
The findings not only confirm the predictive power of CD25 expression for Philadelphia chromosome translocation (Ph)+ but also demonstrate that CD25 expression is associated with RD (a biomarker correlated with prognosis) in Ph- patients. The latter finding is likely associated with underlying molecular abnormalities, including Ph-like genotype.
Through GWAS, we found that emotion dysregulation is associated at genome-wide level significance in a sex-specific manner, with a SNP in IL2RA in men.
it has been shown that CD25 serves as a negative growth regulator of Chronic myeloid leukemia (show BCL11A Proteins) leukemic stem cells.
study provides evidence that membrane-coated microvesicles released by apoptotic neutrophils suppress a subset of resting Th cells by downregulating IL-2 (show IL2 Proteins) and IL-2R expression
In T1D, low IL-2 (show IL2 Proteins) responsiveness was most pronounced in memory T effector cells. Reduced IL-2 (show IL2 Proteins) responses in memory T effector cells were not rescued by resting, remained lower after activation and proliferation, and were absent in type 2 diabetes.
Data indicate that there was a differential transcription of 381 genes which changed greater than two fold in B1a of p40-/-IL-2Ralpha-/- mice.
At single cell level, IL-2 (show IL2 Proteins) is binary (digital) and CD25 is graded expressed, whereas at population level both parameters show graded expression correlating with the antigen amount.
Results indicate that conjugated-interleukin-2 (IL2 (show IL2 Proteins)) protein derived from NKTR (show NKTR Proteins)-214 occupy interleukin-2 (IL2 (show IL2 Proteins)) receptor complex (IL2Ralphabetagamma) to a greater extent compared to free-IL2 (show IL2 Proteins) protein.
CDK6 (show CDK6 Proteins)-mediated suppression of CD25 is required for initiation of T-ALL by activated Notch1 (show NOTCH1 Proteins). . Pharmacologic inhibition of CDK6 (show CDK6 Proteins) kinase induces CD25 and RUNX1 (show RUNX1 Proteins) expression, cell cycle arrest and apoptosis in mouse and human T-ALL.
Combination with anti-programmed cell death protein-1 (PD-1 (show PDCD1 Proteins)) antibodies promoted complete tumor rejection, indicating the relevance of CD25 antigen as a therapeutic target and promising substrate for future combination approaches in immune-oncology.
Intratesticular inoculation with donor antigens promotes long-term skin allograft survival induced by conventional costimulatory blockade via the induction of both CD8 (show CD8A Proteins) + CD122 (show IL2RB Proteins)+ and CD4 (show CD4 Proteins) + CD25+ Treg cells.
glucosamine interferes with N-glycosylation of CD25, and thereby attenuates IL-2 (show IL2 Proteins) downstream signaling
Expansion of CD25-expressing innate lymhpoid cells by IL-2 (show IL2 Proteins)/anti-IL-2 (show IL2 Proteins) complexes leads to a reduction in very low-density lipoprotein cholesterol and atherosclerosis.
our results identify IL-7 (show IL7 Proteins) as a necessary factor contributing to sustained CD25 expression at Treg surface in vivo thereby affecting their ability to efficiently react to IL-2 (show IL2 Proteins).
Data indicate that the deletion of interferon-gamma (IFN-gamma (show IFNG Proteins)) in the CD25 knockout (KO) mice delays glandular destruction and preserves glandular function.
IL2 (show IL2 Proteins)-R was equally expressed in interfollicular tissue and in follicles, whereas in moderate and severe cases of postweaning multisystemic wasting syndrome, it was detected in interfollicular remnants only
The appearance of CD25 after activation of porcine dendritic cells, is reported.
Differential expression of CD25 and IDO (show IDO1 Proteins) mRNA with high and low virulence bovine viral diarrhea virus might reflect temporal differences in transcription during the immune response elicited by these viral strains.
Increase of CD25 expression on bovine neutrophils correlates with mastitis severity in post-partum and early lactating dairy cows.
The PGE2-mediated down-regulation of CD25 expression on T cells is mediated via the EP4 (show PTGER4 Proteins) receptor, although selective activation of the EP2 receptor up-regulates the CD25 expression on these cells.
There is a positive correlation between the intensity of CD25 expression and the expression of the transcription Foxp3 (show FOXP3 Proteins) factor in bovine CD8 (show CD8A Proteins)(+) cells.
determined the effects of Mycobacterium-induced proliferation and apoptosis on CD25, CD44 (show CD44 Proteins), and CD62L (show SELL Proteins) expression on peripheral blood T-cell subsets from M. bovis-infected cattle.
Pretreatment of neonatal PBMC with IL-1beta (show IL1B Proteins), TNF-alpha (show TNF Proteins) or IFN-gamma (show IFNG Proteins) promotes mitogenic response to ConA through up-regulating the production of IL-2 (show IL2 Proteins) and the expression of the mature IL-2 (show IL2 Proteins) receptor.
These findings revealed that despite the existence of a distinct bovine CD4 (show CD4 Proteins)(+)CD25(high) T cell population, which showed Foxp3 (show FOXP3 Proteins) transcription/expression, natural regulatory activity did not reside in this cell population
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
IL-2 receptor subunit alpha
, IL-2R subunit alpha
, TAC antigen
, interleukin-2 receptor subunit alpha
, IL-2 receptor alpha subunit
, interleukin 2 receptor, alpha chain
, interleukin-2 receptor alpha chain
, IL-2 alpha receptor
, IL2 receptor alpha
, interleukin-2 alpha receptor
, interleukin 2 receptor alpha chain
, interleukin-2 receptor alpha subunit
, IL-2 Receptor alpha chain
, interleukin 2 receptor, alpha
, IL-2R alpha chain
, p55 chain
, IL-2R alpha
, cytokine receptor
, CD25 antigen