Quick Overview for CD25 Protein (AA 22-236) (Fc Tag) (ABIN7491125)
Target
See all CD25 (IL2RA) ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 22-236
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Purification tag / Conjugate
- This CD25 protein is labelled with Fc Tag.
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Purpose
- Recombinant mouse IL2RA protein with C-terminal human Fc tag
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Specificity
- Mouse IL2RA(Glu22-Lys236) hFc(Glu99-Ala330)
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Characteristics
- Extracellular Domain Protein
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Purification
- Purified from cell culture supernatant by affinity chromatography
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Interleukin 2 Receptor, alpha (IL2RA) (AA 22-213) protein (His-Avi Tag)
IL2RA Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 2 Receptor, alpha (IL2RA) (AA 22-213) (Active) protein (Biotin,His-Avi Tag)IL2RA Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Interleukin 2 Receptor, alpha (IL2RA) (AA 22-213) protein (His tag)IL2RA Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ScA, IA, ADA, AM
Interleukin 2 Receptor, alpha (IL2RA) (AA 22-213) (Active) protein (Fc Tag)IL2RA Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Interleukin 2 Receptor, alpha (IL2RA) (AA 22-240) protein (hIgG-His-tag)IL2RA Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 90 % SDS
Interleukin 2 Receptor, alpha (IL2RA) protein (His tag)IL2RA Origin: Mouse Host: HEK-293 Cells Recombinant > 98 % as determined by SDS-PAGE
Interleukin 2 Receptor, alpha (IL2RA) (AA 22-213) (Active) protein (His tag,AVI tag,Biotin)IL2RA Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
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Application Notes
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Extracellular Domain Proteins (ECD) can be used as:
- Immunogens for antibody drug development
- Reagents used for CAR-T positive cell monitoring
- Reagents for antibody screening and functional testing
- Reagents for antibody affinity measurement
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Comment
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The protein was produced using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please see Certificate of Analysis for specific instructions of reconstitution.
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Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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Expiry Date
- 12 months
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- CD25 (IL2RA) (Interleukin 2 Receptor, alpha (IL2RA))
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Alternative Name
- IL2RA
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Background
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IL-2-RA,IL2-RA,p55,CD25,Il2ra
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.[UniProtKB/Swiss-Prot Function] -
Molecular Weight
- predicted molecular mass of 50.8 kDa after removal of the signal peptide. The apparent molecular mass of mIL2RA-hFc is 70-100 kDa due to glycosylation.
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UniProt
- P01590
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Pathways
- JAK-STAT Signaling, Growth Factor Binding, Activated T Cell Proliferation
Target
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