CD25 Protein (AA 22-213) (Fc Tag)
Quick Overview for CD25 Protein (AA 22-213) (Fc Tag) (ABIN2181381)
Target
See all CD25 (IL2RA) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 22-213
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Purification tag / Conjugate
- This CD25 protein is labelled with Fc Tag.
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Sequence
- AA 22-213
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Characteristics
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 48.4 Kda. The protein migrates as 60-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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Sterility
- 0.22 μm filtered
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Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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Interleukin 2 Receptor, alpha (IL2RA) (AA 22-213) protein (His-Avi Tag)
IL2RA Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 2 Receptor, alpha (IL2RA) (AA 22-213) (Active) protein (Biotin,His-Avi Tag)IL2RA Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Interleukin 2 Receptor, alpha (IL2RA) (AA 22-213) protein (His tag)IL2RA Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ScA, IA, ADA, AM
Interleukin 2 Receptor, alpha (IL2RA) (AA 22-240) protein (hIgG-His-tag)IL2RA Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 90 % SDS
Interleukin 2 Receptor, alpha (IL2RA) (AA 22-236) protein (Fc Tag)IL2RA Origin: Mouse Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ScA, IA, ADA, AM
Interleukin 2 Receptor, alpha (IL2RA) protein (His tag)IL2RA Origin: Mouse Host: HEK-293 Cells Recombinant > 98 % as determined by SDS-PAGE
Interleukin 2 Receptor, alpha (IL2RA) (AA 22-213) (Active) protein (His tag,AVI tag,Biotin)IL2RA Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Tris with Glycine, Arginine and NaCl, pH 7.5
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Handling Advice
- Please avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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- CD25 (IL2RA) (Interleukin 2 Receptor, alpha (IL2RA))
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Alternative Name
- IL-2 R alpha
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Background
- Interleukin-2 receptor subunit alpha (IL2RA) is also known as IL-2R subunit alpha, IL-2-RA, IL2-RA, TAC antigen, p55, CD antigen CD25, is a type I transmembrane glycoprotein. IL2RA is expressed on activated T cells and regulatory T cells, and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covelently with the IL2 receptor beta and gamma chain, and subsequently initiates the intacellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been previously regarded as an activation marker, while both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling.
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Molecular Weight
- 48.4 kDa
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NCBI Accession
- NP_000408
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Pathways
- JAK-STAT Signaling, Growth Factor Binding, Activated T Cell Proliferation
Target
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