anti-Mouse (Murine) IL2 Receptor beta antibody for Immunoprecipitation

Recommended IL2 Receptor beta Antibody (supplied by: Log in to see )

Antigen
Interleukin 2 Receptor, beta (IL2RB) Antibodies
  • IL2RB
  • il-2rb
  • CD122
  • IL15RB
  • P70-75
  • IL2RBC
  • IL-15Rbeta
  • IL15Rbeta
  • Il-2/15Rbeta
  • Il-2Rbeta
  • p70
  • interleukin 2 receptor subunit beta
  • interleukin-2 receptor subunit beta
  • interleukin 2 receptor, beta
  • interleukin 2 receptor, beta chain
  • IL2RB
  • LOC510185
  • il2rb
  • Il2rb
Reactivity
Mouse (Murine)
224
188
98
29
10
1
1
Host
Rat
143
135
93
Clonality
Monoclonal
Conjugate
This IL2 Receptor beta antibody is un-conjugated
32
31
23
15
9
8
6
6
6
6
6
5
4
4
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Application
Blocking Reagent (BR), Flow Cytometry (FACS), Immunoprecipitation (IP)
221
127
63
58
41
26
15
14
11
10
5
5
4
2
2
1
1
1
1
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Catalog No. ABIN1177313
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2688930 FACS IP Rat IgG2a, kappa Log in to see 5H4 2
1 ABIN476036 FACS IP Neut Rat IgG2b Log in to see TM-b1 (TM-beta1) 0
1 ABIN371157 FACS IP Rat IgG2a Log in to see 5H4 4
1 ABIN120201 FACS IP Rat IgG2b Log in to see TM-BETA1 1
1 ABIN120202 FACS IP Rat IgG2b Log in to see TM-BETA1 1
1 ABIN320231 FACS IP Rat IgG2b Log in to see TM-BETA 1 1
1 ABIN594131 FACS IP Rat IgG2b Log in to see 0
1 ABIN594133 FACS IP Rat IgG2b Log in to see 0
1 ABIN120200 Func FACS IP Rat IgG2b Log in to see TM-BETA1 1
1 ABIN371156 FACS IP Rat IgG2a Log in to see 5H4 0
1 ABIN2478329 Func FACS IP Rat IgG2b Log in to see TM-BETA 1 3
1 ABIN2478322 FACS IP Rat IgG2b Log in to see TM-BETA 1 3
1 ABIN2609870 FACS IP Rat IgG2a Log in to see 5H4 0
1 ABIN217997 FACS IP Biotin Rat IgG2a, kappa Log in to see 0
1 ABIN217996 FACS IP FITC Rat IgG2a, kappa Log in to see 0
1 ABIN594132 Func FACS IP Rat IgG2b Log in to see 0
1 ABIN2609867 FACS IP Biotin Rat IgG2a Log in to see 5H4 0
1 ABIN1826854 FACS IP Biotin Rat IgG2a Log in to see 5H4 0
1 ABIN206813 FACS IP FITC Rat IgG2b Log in to see 0
1 ABIN217995 FACS IP Rat IgG2a, kappa Log in to see 0

General

Antigen Interleukin 2 Receptor, beta (IL2RB) Antibodies
Reactivity Mouse (Murine)
(224), (188), (98), (29), (10), (1), (1)
Host Rat
(143), (135), (93)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IL2 Receptor beta antibody is un-conjugated
(32), (31), (23), (15), (9), (8), (6), (6), (6), (6), (6), (5), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Application Blocking Reagent (BR), Flow Cytometry (FACS), Immunoprecipitation (IP)
(221), (127), (63), (58), (41), (26), (15), (14), (11), (10), (5), (5), (4), (2), (2), (1), (1), (1), (1)
Pubmed 18 references available
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Product Details anti-IL2 Receptor beta Antibody

Target Details IL2 Receptor beta Application Details Handling References for anti-IL2 Receptor beta antibody (ABIN1177313) Images
Brand BD Pharmingen™
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Sterility 0.2 μm filtered
Endotoxin Level Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
Immunogen Flow cytometry, Immunoprecipitation
Clone TM-beta 1
Isotype IgG2b, kappa
Plasmids, Primers & others

Target Details IL2 Receptor beta

Product Details anti-IL2 Receptor beta Antibody Application Details Handling References for anti-IL2 Receptor beta antibody (ABIN1177313) Images back to top
Antigen
Alternative Name CD122 (IL2RB Antibody Abstract)
Background The TM-beta1 antibody reacts with the 90-100-kDa beta chain shared by the IL-2 and IL-15 receptors (IL-2Rbeta, CD122). In the periphery, CD122 is expressed on CD8+ T lymphocytes, NK cells, NK-T cells, dendritic epidermal T cells, subsets of intraepithelial lymphocytes, and macrophages. Small subsets of fetal and adult thymocytes constitutively express CD122. CD122+ cells in the bone marrow include committed NK-cell progenitors. IL-2Rbeta expression is upregulated by IL-2. CD122 is a transmembrane glycoprotein of the hematopoietin receptor superfamily which can combine with CD132 (gammac) alone or CD132 plus CD25 (IL-2Ralpha) to form intermediate or high-affinity IL-2 receptor complexes, respectively. The beta chain of these complexes, CD122, is involved in signal transduction and immunoregulation. The TM-beta1 antibody blocks high affinity binding of IL-2 or IL-15 to IL-2Rbeta.
Synonyms: IL-2 and IL-15 Receptor beta Chain
Pathways JAK-STAT Signaling, Growth Factor Binding

Application Details

Product Details anti-IL2 Receptor beta Antibody Target Details IL2 Receptor beta Handling References for anti-IL2 Receptor beta antibody (ABIN1177313) Images back to top
Restrictions For Research Use only

Handling

Product Details anti-IL2 Receptor beta Antibody Target Details IL2 Receptor beta Application Details References for anti-IL2 Receptor beta antibody (ABIN1177313) Images back to top
Format Liquid
Concentration 1.0 mg/mL
Buffer No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
Preservative Azide free
Storage 4 °C
Storage Comment Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

References for anti-IL2 Receptor beta antibody (ABIN1177313)

Product Details anti-IL2 Receptor beta Antibody Target Details IL2 Receptor beta Application Details Handling Images back to top
Product cited in:

Rosmaraki, Douagi, Roth, Colucci, Cumano, Di Santo: "Identification of committed NK cell progenitors in adult murine bone marrow." in: European journal of immunology, Vol. 31, Issue 6, pp. 1900-9, 2001

Ku, Murakami, Sakamoto, Kappler, Marrack: "Control of homeostasis of CD8+ memory T cells by opposing cytokines." in: Science (New York, N.Y.), Vol. 288, Issue 5466, pp. 675-8, 2000

Cho, Wang, Sugawa, Eisen, Chen: "Functional differences between memory and naive CD8 T cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 6, pp. 2976-81, 1999

Zhang, Sun, Hwang, Tough, Sprent: "Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15." in: Immunity, Vol. 8, Issue 5, pp. 591-9, 1998

Alleva, Kaser, Monroy, Fenton, Beller: "IL-15 functions as a potent autocrine regulator of macrophage proinflammatory cytokine production: evidence for differential receptor subunit utilization associated with stimulation or inhibition." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 6, pp. 2941-51, 1997

Guy-Grand, Cuénod-Jabri, Malassis-Seris, Selz, Vassalli: "Complexity of the mouse gut T cell immune system: identification of two distinct natural killer T cell intraepithelial lineages." in: European journal of immunology, Vol. 26, Issue 9, pp. 2248-56, 1996

Bendelac: "Mouse NK1+ T cells." in: Current opinion in immunology, Vol. 7, Issue 3, pp. 367-74, 1995

Malek, Furse, Fleming, Fadell, He: "Biochemical identity and characterization of the mouse interleukin-2 receptor beta and gamma c subunits." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 15, Issue 5, pp. 447-54, 1995

Suzuki, Kündig, Furlonger, Wakeham, Timms, Matsuyama, Schmits, Simard, Ohashi, Griesser: "Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta." in: Science (New York, N.Y.), Vol. 268, Issue 5216, pp. 1472-6, 1995

Hanke, Mitnacht, Boyd, Hünig: "Induction of interleukin 2 receptor beta chain expression by self-recognition in the thymus." in: The Journal of experimental medicine, Vol. 180, Issue 5, pp. 1629-36, 1994

Kondo, Ohashi, Tada, Nakamura, Sugamura: "Expression of the mouse interleukin-2 receptor gamma chain in various cell populations of the thymus and spleen." in: European journal of immunology, Vol. 24, Issue 9, pp. 2026-30, 1994

Giri, Ahdieh, Eisenman, Shanebeck, Grabstein, Kumaki, Namen, Park, Cosman, Anderson: "Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15." in: The EMBO journal, Vol. 13, Issue 12, pp. 2822-30, 1994

Ohno, Ono, Hirayama, Shimada, Saito: "Preferential usage of the Fc receptor gamma chain in the T cell antigen receptor complex by gamma/delta T cells localized in epithelia." in: The Journal of experimental medicine, Vol. 179, Issue 1, pp. 365-9, 1994

Taniguchi, Minami: "The IL-2/IL-2 receptor system: a current overview." in: Cell, Vol. 73, Issue 1, pp. 5-8, 1993

Nakanishi, Hirose, Yoshimoto, Ishizashi, Hiroishi, Tanaka, Kono, Miyasaka, Taniguchi, Higashino: "Role and regulation of interleukin (IL)-2 receptor alpha and beta chains in IL-2-driven B-cell growth." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 8, pp. 3551-5, 1992

Takeuchi, Tanaka, Hamamura, Sugimoto, Miyasaka, Yagita, Okumura: "Expression and role of interleukin-2 receptor beta chain on CD4-CD8- T cell receptor alpha beta+ cells [corrected]." in: European journal of immunology, Vol. 22, Issue 11, pp. 2929-35, 1992

Tanaka, Takeuchi, Shiohara, Kitamura, Nagasaka, Hamamura, Yagita, Miyasaka: "In utero treatment with monoclonal antibody to IL-2 receptor beta-chain completely abrogates development of Thy-1+ dendritic epidermal cells." in: International immunology, Vol. 4, Issue 4, pp. 487-91, 1992

Tanaka, Tsudo, Karasuyama, Kitamura, Kono, Hatakeyama, Taniguchi, Miyasaka: "A novel monoclonal antibody against murine IL-2 receptor beta-chain. Characterization of receptor expression in normal lymphoid cells and EL-4 cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 147, Issue 7, pp. 2222-8, 1991