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Our data define the mechanisms by which SL-101 targets acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins))and warrant further investigation of the clinical application of SL-101 and other CD123-targeting strategies in AML (show RUNX1 Proteins).
Data show that the N-terminal domain (NTD) of interleukin 3 receptor subunit alpha (IL3Ralpha) exhibits exquisite flexibility and a dynamic transition from a high to a low mobility state upon cytokine binding.
the oncogenic events of FLT3 (show FLT3 Proteins)/ITD happen at a cell stage possessing CD123
IL-3 (show IL-3 Proteins) hardly down-regulates the alpha-chain (show FCGRT Proteins) of its receptor without depleting the common beta-chain (show CSF2RB Proteins), which enables extraordinarily sustained signaling events, predominantly the activation of Stat5 (show STAT5A Proteins).
Data indicate that CD123 was preferentially expressed among CD33 (show CD33 Proteins)/CD117-positive precursor-T-acute lymphoblastic leukemia (T-ALL).
CD123 positivity represents a marker that can facilitate identification of the early T-cell precursor leukemia subtype, but the lack of sensitivity by immunohistochemistry limits the diagnostic utility.
CD123 expression is associated with systemic mastocytosis.
Our results suggest that the CD34 (show CD34 Proteins)/CD25 (show IL2RA Proteins)/CD123/CD99 (show CD99 Proteins)(+) LAIP is strictly associated with FLT3 (show FLT3 Proteins)-ITD-positive cells.
Human BDCA2+CD123+CD56 (show NCAM1 Proteins)+ dendritic cells (DCs) related to blastic plasmacytoid dendritic cell neoplasm represent a unique myeloid DC subset.
CD96 (show CD96 Proteins) and CD123 are expressed in bone marrow cells of patients with myelodysplastic syndromes
expression of the interleukin 3 receptor alpha (Il3ra also known as Cd123) subunit is dependent on Jmjd2 (show KDM4A Proteins)/Kdm4 through a mechanism involving removal of H3K9me3 from the promoter of the Il3ra gene.
Data indicate that the proliferative and differentiative effect of saponins from Sanguisorba officinalis (DYS) on megakaryocyte progenitor cells is correlated to the up-regulation of IL-3 receptor and c-kit expression.
Findings indicate that SLP-76 (show LCP2 Proteins) is an essential signaling component for basophil activation downstream of both FcepsilonRI (show FCER1A Proteins) and the IL-3 (show IL-3 Proteins) receptor.
Interleukin-3 (show IL-3 Proteins)/dendritic cells expressed higher levels of interleukin-3 (show IL-3 Proteins) receptor.
The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found.
, IL-3 receptor alpha SP2 isoform
, IL-3 receptor subunit alpha
, IL-3R subunit alpha
, interleukin-3 receptor subunit alpha
, IL-3 receptor alpha chain
, Il-3 alpha subunit
, interleukin-3 receptor class II alpha chain
, cytokine receptor-like protein CYRL
, interleukin 3 receptor, alpha chain