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|Antigen||Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This STAT1 antibody is un-conjugated Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|3 references available|
Product Details anti-STAT1 AntibodyTarget Details STAT1 Application Details Handling References for anti-STAT1 antibody (ABIN674889) Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human STAT1|
|Plasmids, Primers & others|
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|Alternative Name||Stat1 (STAT1 Antibody Abstract)|
Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
Subcellular location: Cytoplasm, Nucleus
Synonyms: CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91, Signal transducer and activator of transcription 1-alpha/beta, Transcription factor ISGF-3 components p91/p84, STAT1
|Pathways||JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events|
Application DetailsProduct Details anti-STAT1 Antibody Target Details STAT1 Handling References for anti-STAT1 antibody (ABIN674889) Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-STAT1 Antibody Target Details STAT1 Application Details References for anti-STAT1 antibody (ABIN674889) Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|
References for anti-STAT1 antibody (ABIN674889)Product Details anti-STAT1 Antibody Target Details STAT1 Application Details Handling Images back to top
|Product cited in:||
Chen, Ding, Li, Huang, Li, Yang, Zhang, Pan, Huang, Meng, Li: "Hesperetin derivative-14 alleviates inflammation by activating PPAR-γ in mice with CCl4-induced acute liver injury and LPS-treated RAW264.7 cells." in: Toxicology letters, Vol. 274, pp. 51-63, 2017 Method employed by authors: Western Blotting (WB), Western Blotting (WB) (Sample species: Mouse (Murine)).
Zhou, Lu, Wang, Xiao, Liu, Xing: "microRNA let-7c is essential for the anisomycin-elicited apoptosis in Jurkat T cells by linking JNK1/2 to AP-1/STAT1/STAT3 signaling." in: Scientific reports, Vol. 6, pp. 24434, 2016 Method employed by authors: Western Blotting (WB) (Sample species: Human).
Wang, Wang, Song, Chu, Qu: "Deficiency of interferon-gamma or its receptor promotes colorectal cancer development." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 35, Issue 4, pp. 273-80, 2015 Method employed by authors: Western Blotting (WB) (Sample species: Mouse (Murine)). Further details: Sample: Intestinal tracts and adenomas
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