Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

MPL ELISA Kit

MPL Reactivity: Mouse AA 26-482 Colorimetric Sandwich ELISA
Catalog No. ABIN5510636
  • Target See all MPL ELISA Kits
    MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))
    Binding Specificity
    AA 26-482
    Reactivity
    • 2
    • 1
    • 1
    Mouse
    Detection Method
    Colorimetric
    Method Type
    Sandwich ELISA
    Application
    ELISA
    Purpose
    Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse TPOR/MPL
    Brand
    PicoKine™
    Analytical Method
    Quantitative
    Specificity
    Expression system for standard: NSO
    Immunogen sequence: Q26-W482
    Cross-Reactivity (Details)
    There is no detectable cross-reactivity with other relevant proteins.
    Top Product
    Discover our top product MPL ELISA Kit
  • Plate
    Pre-coated
    Restrictions
    For Research Use only
  • Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
    Expiry Date
    12 months
  • Target See all MPL ELISA Kits
    MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))
    Alternative Name
    Mpl (MPL Products)
    Synonyms
    C-MPL ELISA Kit, CD110 ELISA Kit, MPLV ELISA Kit, THCYT2 ELISA Kit, TPOR ELISA Kit, TPO-R ELISA Kit, c-mpl ELISA Kit, c-mpl-I ELISA Kit, c-mpl-II ELISA Kit, hlb219 ELISA Kit, MPL ELISA Kit, mpll ELISA Kit, tpor ELISA Kit, tpor.b ELISA Kit, MPL proto-oncogene, thrombopoietin receptor ELISA Kit, myeloproliferative leukemia virus oncogene ELISA Kit, MPL ELISA Kit, Mpl ELISA Kit, mpl ELISA Kit
    Background

    Protein Function: Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses.

    Background: The thrombopoietin receptor (TPOR), also known as CD110, is a protein that in humans is encoded by the MPL (myeloproliferative leukemia virus) oncogene. The human MPL gene is mapped to chromosome 1p34. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

    Synonyms: Thrombopoietin receptor,TPO-R,Myeloproliferative leukemia protein,Proto-oncogene c-Mpl,CD110,Mpl,Tpor,

    Full Gene Name: Thrombopoietin receptor

    Cellular Localisation: Cell membrane, Single-pass type I membrane protein . Golgi apparatus . Cell surface.
    UniProt
    Q08351
    Pathways
    JAK-STAT Signaling
You are here:
Support