DR3/LARD ELISA Kit

Catalog No. ABIN5510736

Product Details DR3/LARD ELISA Kit

Target: DR3/LARD (TNFRSF25) (Tumor Necrosis Factor Receptor Superfamily, Member 25 (TNFRSF25))

Binding Specificity: AA 25-201

Reactivity: Human

Detection Method: Colorimetric

Method Type: Sandwich ELISA

Application: ELISA

Purpose: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human TNFRSF25/DR3

Brand: PicoKine™

Analytical Method: Quantitative

Specificity: Expression system for standard: NSO, Immunogen sequence: Q25-F201

Cross-Reactivity (Details): There is no detectable cross-reactivity with other relevant proteins.

Characteristics:

Tissue Specificity: Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.

Application Details

Plate: Pre-coated

Restrictions: For Research Use only

Handling

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Expiry Date: 12 months

Target Details for DR3/LARD

Target: DR3/LARD (TNFRSF25) (Tumor Necrosis Factor Receptor Superfamily, Member 25 (TNFRSF25))

Alternative Name: TNFRSF25 (TNFRSF25 Products)

Synonyms: APO-3 ELISA Kit, DDR3 ELISA Kit, DR3 ELISA Kit, LARD ELISA Kit, TNFRSF12 ELISA Kit, TR3 ELISA Kit, TRAMP ELISA Kit, WSL-1 ELISA Kit, WSL-LR ELISA Kit, Tnfrsf12 ELISA Kit, Wsl ELISA Kit, TNFRSF25 ELISA Kit, TNF receptor superfamily member 25 ELISA Kit, tumor necrosis factor receptor superfamily, member 25 ELISA Kit, TNFRSF25 ELISA Kit, Tnfrsf25 ELISA Kit

Background:

Protein Function: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.

Background: Death receptor 3 (DR3), also known as tumor necrosis factor receptor superfamily member 25 (TNFRSF25), is a cell surface receptor of the tumor necrosis factor receptor superfamily which mediates apoptotic signalling and differentiation. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.

Synonyms: Tumor necrosis factor receptor superfamily member 25,Apo-3,Apoptosis-inducing receptor AIR,Apoptosis-mediating receptor DR3,Apoptosis-mediating receptor TRAMP,Death receptor 3,Lymphocyte-associated receptor of death,LARD,Protein WSL,Protein WSL-1,TNFRSF25,APO3, DDR3, DR3, TNFRSF12, WSL, WSL1,UNQ455/PRO779,

Full Gene Name: Tumor necrosis factor receptor superfamily member 25

Cellular Localisation: Isoform 1: Cell membrane, Single-pass type I membrane protein.

UniProt: Q93038

Pathways: Apoptosis