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Here, we found that centrosomal protein of 76 kDa (Cep76), previously shown to restrain centriole amplification, interacts with cyclin-dependent kinase 2 (CDK2 (show CDK2 Proteins)) and is a bona fide substrate of this kinase. Cep76 is preferentially phosphorylated by cyclin A (show CCNA2 Proteins)/CDK2 (show CDK2 Proteins) at a single site S83, and this event is crucial to suppress centriole amplification in S phase
Enforced Cep76 expression specifically inhibits centriole amplification in cells undergoing multiple rounds of duplication without preventing the formation of extra procentrioles from a parental template.
This gene encodes a centrosomal protein which regulates centriole amplification by limiting centriole duplication to once per cell cycle. Alternative splicing results in multiple transcript variants.
centrosomal protein 76kDa
, centrosomal protein of 76 kDa
, centrosomal protein of 76 kDa-like