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MAK Products

(Male Germ Cell-Associated Kinase (MAK))

Categories

The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].

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Featured MAK Categories

MAK Antibodies

High quality antibodies with extensive validation data.

MAK ELISA Kits

Reliable ELISA kits for a wide range of species.

MAK Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MAK Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (6)
Cat. No. ABIN517720
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
  • (3)
Cat. No. ABIN391782
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (4)
Cat. No. ABIN7268382
Quantity 100 μL
Datasheet Datasheet

Recommended MAK ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1381289
Quantity 96 tests
Datasheet Datasheet

Recommended MAK Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1310104
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1310103
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3093753
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our MAK products

Li, Rao, Zheng-Le, Hurd, Lillo, Khanna: "Loss of retinitis pigmentosa 2 (RP2) protein affects cone photoreceptor sensory cilium elongation in mice." in: Cytoskeleton (Hoboken, N.J.), (2015) (PubMed).

Tucker, Scheetz, Mullins, DeLuca, Hoffmann, Johnston, Jacobson, Sheffield, Stone: "Exome sequencing and analysis of induced pluripotent stem cells identify the cilia-related gene male germ cell-associated kinase (MAK) as a cause of retinitis pigmentosa." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 34, pp. E569-76, (2011) (PubMed).

Ma, Xia, Desai, Boucher, Guan, Shih, Shi, deVere White, Chen, Tepper, Kung: "Male germ cell-associated kinase, a male-specific kinase regulated by androgen, is a coactivator of androgen receptor in prostate cancer cells." in: Cancer research, Vol. 66, Issue 17, pp. 8439-47, (2006) (PubMed).

Fu, Larson, Chitta, Parker, Turk, Lawrence, Kaldis, Galaktionov, Cohn, Shabanowitz, Hunt, Sturgill: "Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase." in: Molecular and cellular biology, Vol. 26, Issue 22, pp. 8639-54, (2006) (PubMed).

Mungall, Palmer, Sims, Edwards, Ashurst, Wilming, Jones, Horton, Hunt, Scott, Gilbert, Clamp, Bethel, Milne, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey, Banerjee, Barker et al.: "The DNA sequence and analysis of human chromosome 6. ..." in: Nature, Vol. 425, Issue 6960, pp. 805-11, (2003) (PubMed).

Xia, Robinson, Ma, Chen, Wu, Qiu, Kung: "Identification of human male germ cell-associated kinase, a kinase transcriptionally activated by androgen in prostate cancer cells." in: The Journal of biological chemistry, Vol. 277, Issue 38, pp. 35422-33, (2002) (PubMed).

Woodle, Newman, Cohen: "Sterically stabilized liposomes: physical and biological properties." in: Journal of drug targeting, Vol. 2, Issue 5, pp. 397-403, (1995) (PubMed).

Synonyms and alternative names related to MAK

male germ cell associated kinase (MAK), male germ cell-associated kinase (Mak), male germ cell-associated kinase (mak), male germ cell associated kinase L homeolog (mak.L), male germ cell associated kinase (mak), A930010O05Rik, dJ417M14.2, fj04c02, Ick, MGC82717, MGC146434, RP62, rp62, wu:fj04c02, xmak, zgc:56603

Protein level used designations for MAK

  • male germ cell-associated kinase retinal-enriched isoform
  • serine/threonine protein kinase MAK
  • serine/threonine-protein kinase MAK
  • protein kinase RCK
  • intestinal cell kinase
  • male germ cell-associated kinase
  • serine/threonine-protein kinase MAK-like
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