|Antigen||Jun Proto-Oncogene (JUN) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This C-JUN antibody is un-conjugated Alternatives|
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Western Blotting (WB)
|7 references available|
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Product Details anti-C-JUN AntibodyTarget Details C-JUN Application Details Handling References for anti-C-JUN antibody (ABIN967578) Images
|Cross-Reactivity (Details)||Predicted: Mouse, Rat|
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
|Purification||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
Target Details C-JUNProduct Details anti-C-JUN Antibody Application Details Handling References for anti-C-JUN antibody (ABIN967578) Images back to top
|Alternative Name||C-Jun (JUN Antibody Abstract)|
The activator protein transcription factor (AP-1) was identified as a protein that recognizes specific sequences in the cis-control regions of the SV40 virus and the human metallothionein IIA gene. AP-1 is composed of protein products of two different gene families: jun and fos. The AP-1 transcription factor is either a homodimer of Jun proteins or a heterodimer of Jun and Fos proteins. The transcriptional activity of Jun is enhanced by phosphorylation of serines 63 (S63) and 73 in its activation domain. Phosphorylation at both sites is necessary for stimulating the activating function of Jun. Jun is phosphorylated by JNK protein kinases that are activated by the same signals that potentiate Jun activity.
The 2/c-Jun/(S63) monoclonal antibody recognizes the phosphorylated S63 of c-Jun.
|Molecular Weight||39 kDa|
|Pathways||MAPK Signaling, RTK Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Autophagy, Signaling of Hepatocyte Growth Factor Receptor|
Application DetailsProduct Details anti-C-JUN Antibody Target Details C-JUN Handling References for anti-C-JUN antibody (ABIN967578) Images back to top
Related Products: ABIN967389
|Restrictions||For Research Use only|
HandlingProduct Details anti-C-JUN Antibody Target Details C-JUN Application Details References for anti-C-JUN antibody (ABIN967578) Images back to top
|Buffer||Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store undiluted at -20°C.|
References for anti-C-JUN antibody (ABIN967578)Product Details anti-C-JUN Antibody Target Details C-JUN Application Details Handling Images back to top
|Product cited in:||
Weiss, Bohmann: "Deregulated repression of c-Jun provides a potential link to its role in tumorigenesis." in: Cell cycle (Georgetown, Tex.), Vol. 3, Issue 2, pp. 111-3, 2004
Dunn, Wiltshire, MacLaren, Gillespie: "Molecular mechanism and biological functions of c-Jun N-terminal kinase signalling via the c-Jun transcription factor." in: Cellular signalling, Vol. 14, Issue 7, pp. 585-93, 2002
Shaulian, Karin: "AP-1 in cell proliferation and survival." in: Oncogene, Vol. 20, Issue 19, pp. 2390-400, 2001
Behrens, Sibilia, Wagner: "Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation." in: Nature genetics, Vol. 21, Issue 3, pp. 326-9, 1999
Wisdom, Johnson, Moore: "c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms." in: The EMBO journal, Vol. 18, Issue 1, pp. 188-97, 1999
Smeal, Binetruy, Mercola, Grover-Bardwick, Heidecker, Rapp, Karin: "Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73." in: Molecular and cellular biology, Vol. 12, Issue 8, pp. 3507-13, 1992
Lamph, Wamsley, Sassone-Corsi, Verma: "Induction of proto-oncogene JUN/AP-1 by serum and TPA." in: Nature, Vol. 334, Issue 6183, pp. 629-31, 1988
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