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FOXE1 (show FOXE1 Proteins) interacts with ELK1 on thyroid relevant gene promoters, establishing a new regulatory pathway for its role in adult thyroid function. Co-regulation of TERT (show TERT Proteins) suggests a mechanism by which allelic variants in/near FOXE1 (show FOXE1 Proteins) are associated with thyroid cancer risk.
Data suggest that inability of lithium, an anti-manic agent, to regulate circadian rhythms in cells from patient with bipolar disorder reflects reduced ERK1/2 activity and MAP kinase (show MAPK1 Proteins) signaling through ELK1. (ERK (show EPHB2 Proteins) = extracellular signal-related kinase; ELK1 = ETS-domain protein (show ELK3 Proteins) ELK1)
we have shown that miR (show MLXIP Proteins)-1275 is a novel negative regulator of human visceral preadipocyte differentiation, which appears to act via post-transcriptional silencing of ELK1.
Purified ELK1 and AR bound with a dissociation constant of 1.9 x 10(-8) m A purified mutant ELK1 in which the D-box and DEF motifs were disrupted did not bind AR.
Study identified ELK1 as a novel target for miR (show MLXIP Proteins)- 150 which is up-regulated in apoptotic human umbilical cord vein endothelial cells.
Study identified a core region encompassing nt - 118 to + 108 of IPO4 gene that is necessary for its promoter activity. Transcription factors binding to this region were screened, resulting in the identification of two members of the Ets family, Ets-like transcription factor-1 and GA binding protein, which repress or activate its promoter activity, respectively.
High expression of ELK1 is associated with cholangiocarcinoma.
Overexpression of PAD4 (show PADI4 Proteins) constrains the activity of EMT (show ITK Proteins) via suppressing Elk1 expression.
These data reveal a novel role for Elk1 regulating ITGB6 expression and highlight how dysregulation of Elk1 can contribute to human disease.
Downregulated expression of transcriptional activator ELK-1 may play an important role in the pathogenesis of atrial fibrillation.
the effects of vitamin C inhibiting the apo(a) expression were attenuated by ELK1siRNA and Tet2siRNA. These results suggested vitamin C down-regulate apo(a) expression via Tet2-dependent DNA demethylation in HepG2 cells
A role for Elk-1 in the transcriptional regulation of DUSP5 (show DUSP5 Proteins)
TNF-alpha (show TNF Proteins) modulation of intestinal epithelial tight junction barrier is regulated by ERK1/2 activation of Elk-1.
novel GrB-EH(ITSN)-dependent pathogenic p38(MAPK (show MAPK14 Proteins))/Elk-1 signaling pathway involved in the poorly understood process of PL formation in severe PAH.
Data show that formation of a Krupple-like factor KLF4 (show KLF4 Proteins), pELK-1, and histone de-acetylase 2 (HDAC2 (show HDAC2 Proteins)) multiprotein complex dependent on the SM22alpha (show TAGLN Proteins) G/C Repressor element.
increased protein levels, phosphorylation and nuclear localization of Elk-1 observed in exon-1 and full-length Huntington's disease models could be a compensatory mechanism activated by striatal cells that contributes to neuroprotection
Fibroblast growth factor 21 (show FGF21 Proteins) induces glucose transporter-1 (show SLC2A1 Proteins) expression through activation of the serum response factor/Ets (show ETS1 Proteins)-like protein-1 in adipocytes
Elk-1 phosphorylation downstream from extracellular signal-regulated kinase is a key molecular event involved in long-term neuronal and behavioral adaptations to cocaine.
we aimed to identify the critical promoter regions of SPG4 (show SPAST Proteins) gene and effects of Elk1 on SPG4 (show SPAST Proteins) gene expression
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14.
ETS domain-containing protein Elk-1
, ETS-like gene 1
, tyrosine kinase (ELK1) oncogene
, ELK1, member of ETS oncogene family S homeolog
, ternary complex factor Elk-1